摘要
目的 分析与常见不良妊娠结局相关的孕前风险因素,为预防不良妊娠结局提供科学依据。方法 对如皋市2017年1月至2019年12月参加孕前优生健康检查后怀孕的夫妇建立队列,回顾或前瞻性地收集孕前检查结果。采用单因素和多因素配对条件Logistic回归对586对病例和1 172对对照进行分析。结果 单因素分析显示,不良妊娠结局和女性贫血(χ^(2)=7.558,P<0.05)、血糖升高(χ^(2)=3.905,P<0.05)、沙眼衣原体感染(P=0.003)、怀孕史(χ^(2)=5.581,P<0.05)、怀孕次数(χ^(2)=3.982,P<0.05)、肥胖(χ^(2)=14.672,P<0.05)及男性高龄(χ^(2)=6.819,P<0.05)和男科检查异常(χ^(2)=6.094,P<0.05)有关系。多因素分析显示,女性怀孕史(OR=1.293,95%CI:1.013~1.650)、肥胖(OR=2.390,95%CI:1.513~3.776)及男性高龄(OR=3.581,95%CI:1.706~7.514)、男科检查异常(OR=2.754,95%CI:1.251~6.062)可能是不良妊娠结局的危险因素(P<0.05)。结论 应结合孕前风险因素加强对育龄夫妇的健康教育,避免高龄生育、减少非意愿妊娠,促进养成健康生活行为,减少不良妊娠结局的发生。
Objective To analyze the pre-pregnancy risk factors associated with adverse pregnancy outcomes and provide a scientific basis for preventing adverse pregnancy outcomes.Methods A cohort was established for pregnant couples who participated pre-pregnancy health examination in Rugao City from January 2017 to December 2019.The results of pre-pregnancy health examinations were collected retrospectively or prospectively.586 pairs of cases and 1172 pairs of controls were selected and analyzed by univariate logistic regression analysis and 1:2 matched multivariate logistic regression analysis.Results The univariate analysis showed that the adverse pregnancy outcomes were related with anemia(χ^(2)=7.558,P<0.05),elevated blood glucose(χ^(2)=3.905,P<0.05),Chlamydia trachomatis infection(P=0.003),pregnancy history(χ^(2)=5.581,P<0.05),pregnancy times(χ^(2)=3.982,P<0.05),obesity(χ^(2)=14.672,P<0.05),advanced age(male)(χ^(2)=6.819,P<0.05),and abnormal andrology examination(χ^(2)=6.094,P<0.05).The multivariate analysis showed that pregnancy history(OR=1.293,95%CI:1.013~1.650),obesity(OR=2.390,95%CI:1.513~3.776),advanced age(male)(OR=3.581,95%CI:1.706~7.514),and abnormal andrology examination(OR=2.754,95%CI:1.251~6.062) may be risk factors for adverse pregnancy outcomes(P<0.05).Conclusion Health education for couples of childbearing age should be strengthened in combination with pre-pregnancy risk factors, so as to avoid advanced childbearing age and reduce unintended pregnancy, promote the development of healthy life habits, and reduce the incidence of adverse pregnancy outcomes.
作者
林洁
樊荷莲
傅雅丽
李鸿斌
吕年青
周定杰
LIN Jie;FAN Helian;FU Yali;LI Hongbin;LYU Nianqing;ZHOU Dingjie(Jiangsu Health Development Research Center,Jiangsu Nanjing210036,China;National Health Commission Contraceptives Adverse Reaction Surveillance Center,Jiangsu Nanjing 210036,China;Rugao Maternal and Child Health Family Planning Service Center,Jiangsu Nantong 226553,China)
出处
《中国妇幼健康研究》
2022年第11期94-98,共5页
Chinese Journal of Woman and Child Health Research
基金
江苏省卫生计生委医学科研课题(H2018101)
江苏省妇幼健康科研重点项目(F202010)
中国毒理学会临床毒理专项研究课题(CST2020CT403)。
关键词
不良妊娠结局
孕前
风险因素
巢式病例对照研究
adverse pregnancy outcomes
pre-pregnancy
risk factor
nested case-control study
