摘要
研究马钱科醉鱼草属醉鱼草Buddleja lindleyana茎的化学成分。采用聚酰胺、硅胶、MCI、Sephadex LH-20柱色谱、半制备高效液相色谱等技术对醉鱼草茎的95%乙醇提取物进行分离纯化,通过波谱学分析以及X-射线单晶衍射等方法鉴定结构。从中共分离鉴定得到10个化合物:buddledin F(1)、6-O-4″-hydroxy-3″-methoxy-benzoyl ajugol(2)、negundoin G(3)、(+)-dihydrocubebin(4)、7-O-ethylguaiacylglycerol(5)、(-)-jatrointelignan B(6)、threo-1,2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1,3-diol(7)、vomifoliol(8)、hinokinin(9)、isovanillic acid(10)。化合物1为1个新的倍半萜类化合物,命名为buddledin F。化合物3~8为首次从醉鱼草属植物中分离得到。对化合物1~10进行了体外抗炎活性研究,抗炎筛选结果未显示这些化合物对炎症因子NO生成抑制活性。
The present study investigated the chemical constituents from the stems of Buddleja lindleyana.Ten compounds were isolated from the 95%EtOH extract of B.lindleyana stems by means of some techniques including polyamide,silica gel,MCI,Sephadex LH-20 column chromatography,and semi-preparative high-performance liquid chromatography(HPLC).Their structures were identified by spectral analysis and single-crystal X-ray diffraction as buddledin F(1),6-O-4″-hydroxy-3″-methoxy-benzoyl ajugol(2),negundoin G(3),(+)-dihydrocubebin(4),7-O-ethylguaiacylglycerol(5),(-)-jatrointelignan B(6),threo-1,2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1,3-diol(7),vomifoliol(8),hinokinin(9),and isovanillic acid(10).Compound 1 was a new sesquiterpene named buddledin F.Compounds 3-8 were isolated from the Buddleja plant for the first time.The anti-inflammatory activities of compounds 1-10 in vitro were investigated,and the results failed to show the inhibitory activities of these compounds on the production of inflammatory factor NO.
作者
陈钊婵
蔡云霜
庾石山
CHEN Zhao-chan;CAI Yun-shuang;YU Shi-shan(Guangxi University of Chinese Medicine,Nanning 530200,China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第20期5537-5543,共7页
China Journal of Chinese Materia Medica
基金
国家自然科学基金重点项目(21732008)。
关键词
醉鱼草
化学成分
倍半萜
Buddleja lindleyana
chemical constituent
sesquiterpene
