摘要
目的:探讨静脉滴注白蛋白联合间歇光疗法治疗新生儿高胆红素血症(HB)的临床疗效.方法:选择武陟济民医院2018年3月至2022年2月收治的108例新生儿HB患儿为研究对象并进行回顾性分析.按治疗方法不同分为联合组(n=55,静脉滴注白蛋白联合间歇光疗法)和单一组(n=53,仅给予间歇光疗法).比较两组临床疗效、胆红素水平及不良反应.结果:联合组治疗后总有效率为96.36%(53/55),明显高于单一组(83.02%,44/53)(P<0.05).治疗前两组总胆红素(TBIL)、间接胆红素(IBIL)及直接胆红素(DBIL)水平比较,差异无统计学意义(P>0.05);治疗后两组TBIL、IBIL及DBIL水平均较治疗前降低,且联合组上述因子水平均低于单一组(P<0.05).联合组治疗后不良反应总发生率为9.09%(5/55),单一组为3.77%(2/53),组间比较差异无统计学意义(P>0.05).结论:静脉滴注白蛋白联合间歇光疗法治疗新生儿HB可改善患儿胆红素水平,提高临床疗效,且安全可靠.
Objective:To investigate the clinical efficacy of albumin intravenous drip combined with intermittent light therapy in the treatment of neonatal hyperbilirubinemia(HB).Methods:The clinical data of 108 neoates with HB who were admitted to Wuzhi Jimin Hospital from March 2018 to February 2022 were retrospectively analyzed.According to different treatment methods,they were divided into combination group(n=55,albumin intravenous drip combined with intermittent light therapy ouly)and single group(n=53,intermittent light therapy only).The clinical efficacy,bilirubin levels and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate in the combination group was 96.36%(53/55),which was significantly higher than that in the single group with 83.02%(44/53)(P<0.05).Before treatment,there was no significant difference in total bilirubin(TBIL),indirect bilirubin(IBIL)and direct bilirubin(DBIL)between the two groups(P>O.05);before the treatment,the levels of TBIL,IBIL and DBIL in the two groups were lower than those before treatment,and the levels of the above factors in the combined group were lower than those in the single group(P<0.05).The total incidence of adverse reactions after treatment in the combination group was 9.09%(5/55),and that in the single group was 3.77%(2/53).There was no significant difference between the groups(P>O.05).Conclusion:Intravenous albumin infusion combined with intermittent light therapy in the treatment of neonatal HB can improve the bilirubin level,increase the clinical efficacy.It is safe and reliable.
作者
古瑞华
陈秀娟
岳爱武
GU Rui-hua;CHEN Xiu-juan;YUE Ai-wu(Department of Neonatology,Wuzhi Jimin Hospital,Jiaozuo 454950,China;Department of Neonatology,Wuzhi Maternal and Child Health Hospital,Jiaozuo 454950,China)
出处
《四川解剖学杂志》
2022年第3期84-86,132,共4页
Sichuan Journal of Anatomy
关键词
白蛋白
间歇光疗法
高胆红素血症
临床疗效
不良反应
Abumin
Intermittent light therapy
Hyperbilirubemia
Clinical efficacy
Adverse reactions
