摘要
结直肠癌(colorectal cancer,CRC)是常见的消化道恶性肿瘤之一,其发生、发展与饮食、遗传及免疫等多种因素关系密切。目前,大量的基础及临床研究开始聚焦肠道菌群在CRC免疫调控中的作用。本文通过对CRC患者肠道菌群构成、肠道菌群与免疫微环境的关系等作一综述,重点分析CRC患者肠道菌群对肠道免疫微环境的调控,为CRC的预防及治疗提供新的研究思路。
Colorectal cancer(CRC)is one of the most commonly malignant tumors of digestive tract.Its occurrence and development are affected by many factors such as diet,genetics,and immunity.At present,more studies have turned to the role of intestinal flora in immune regulation of CRC.In this review,the composition of intestinal flora and the relationship between intestinal flora and intestinal immune microenvironment in CRC patients are studied,and we emphatically discuss the regulation of intestinal flora in intestinal immune microenvironment in CRC patients in order to provide a new way for the prevention and treatment of CRC.
作者
朱琨
卢清军
任翔
蒋宏
Zhu Kun;Lu Qingjun;Ren Xiang;Jiang Hong(Departments of Colorectal Hernia Surgery,Binzhou Medical University Hospital,Binzhou 256000,China)
出处
《国际医药卫生导报》
2022年第24期3419-3422,共4页
International Medicine and Health Guidance News
基金
国家卫生健康委科技发展中心“微创手术临床应用规范研究”课题(WA2021RW12)
滨州医学院“临床+X”项目基金(BY2021LCX21)
滨州医学院科研计划与科研启动基金(BY2019KYQD42,BY2019KJ11)。
关键词
结直肠癌
肠道菌群
肠道免疫微环境
Colorectal cancer
Intestinal flora
Intestinal immune microenvironment
