摘要
目的:观察加味解毒饮联合西药治疗类风湿性膝关节炎的疗效及对血清正五聚素蛋白-3 (PTX3)、CXCL13表达的影响。方法:选取80例类风湿性膝关节炎患者,按随机数字表法分为研究组及对照组各40例。对照组给予西药治疗,研究组在对照组基础上给予加味解毒饮。2组均治疗24周。观察2组临床疗效及治疗期间不良反应发生情况,比较2组治疗前后中医证候评分、Lysholm膝关节评分、细胞因子[白细胞介素-4 (IL-4)、白细胞介素-6 (IL-6)、白细胞介素-10 (IL-10)、白细胞介素-17 (IL-17)、转化生长因子-β (TGF-β)、干扰素-γ (IFN-γ)水平]、血清PTX3及CXCL13表达的变化。结果:对照组临床疗效总有效率为72.50%,研究组为90.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组关节肿胀、晨僵、酸软乏力、屈伸不利、冷痛、恶风寒及耳鸣头晕评分及总积分均较治疗前下降,差异均有统计学意义(P<0.05);治疗后,研究组上述7项评分及总积分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组Lysholm膝关节评分均较治疗前升高,研究组Lysholm膝关节评分高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组IL-4、IL-10、TGF-β水平均较治疗前升高,IL-6、IL-17、IFN-γ水平均较治疗前下降,差异均有统计学意义(P<0.05);研究组IL-4、IL-10、TGF-β水平均高于对照组,IL-6、IL-17、IFN-γ水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组PTX3水平均较治疗前下降,研究组低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清CXCL13水平均较治疗前下降,研究组低于对照组,差异均有统计学意义(P<0.05)。研究组、对照组治疗期间不良反应发生率分别为7.50%、10.00%,2组比较,差异无统计学意义(P>0.05)。结论:加味解毒饮联合西药可缓解类风湿膝关节炎患者临床症状,提高膝关节功能,改善机体免疫功能,降低血清PTX3及CXCL13表�
Objective: To observe the curative effect of modified Jiedu yin combined with western medicine on rheumatoid arthritis in the knee and its effects on the expression of serum pentraxin-3(PTX3)and CXCL13. Methods:A total of 80 cases of patients with rheumatoid arthritis in the knee were selected and divided into the study group and the control group according to the random number table method,with40 cases in each group. The control group was treated with western medicine,and the study group was additionally treated with modified Jiedu yin based on the treatment of the control group. Both groups were treated for 24 weeks. Clinical effects and the incidence of adverse reactions during treatment were observed in the two groups. Before and after treatment,changes in Chinese medicine syndrome scores,Lysholm knee joint scores,cytokines [levels of interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10),interleukin-17(IL-17),transforming growth factor-β(TGF-β),and interferon-γ(IFN-γ)],and the expression of PTX3 and CXCL13 in serum were compared between the two groups. Results: The total clinical effective rate was 72.50% in the control group, and 90.00% in the study group, the difference being significant(P<0.05). After treatment,the scores of joint swelling,morning stiffness,soreness and fatigue,difficult flexion and extension,cold pain,aversion to wind-cold,tinnitus and dizziness and the total scores in the two groups were decreased when compared with those before treatment,differences being significant(P<0.05);after treatment,the above seven scores and the total score in the study were lower than those in the control group, differences being significant(P<0.05). After treatment, Lysholm knee joint scores in the two groups were increased when compared with those before treatment,and the score in the study group was lower than that in the control group,differences being significant(P<0.05).After treatment,levels of IL-4,IL-10 and TGF-β in the two groups were increased when compared with those before treatment,
作者
夏祖辉
倘艳锋
郭晓辉
陈江非
XIA Zuhui;TANG Yanfeng;GUO Xiaohui;CHEN Jiangfei
出处
《新中医》
CAS
2022年第19期138-143,共6页
New Chinese Medicine
基金
国家自然科学基金项目(81610368)。
