摘要
随着社会经济的发展,人口老龄化进程加剧,全球肿瘤的发生率及死亡率不断上升,肿瘤远期转移是导致患者死亡的重要原因之一。目前国内外已有多项研究表明癌症相关成纤维细胞(carcinoma-associated fibroblasts,CAFs)可以通过多种途径诱导上皮-间质转化(epithelial-mesenchymal transition,EMT)的发生来提高肿瘤细胞的侵袭能力及转移能力。基于目前国内外对CAFs与EMT之间相互关系的研究成果,本文旨在阐述CAFs在消化系统、泌尿生殖系统及其他系统常见肿瘤中促进EMT的近期研究进展,分别对各系统常见肿瘤中CAFs诱导EMT发生的近期机制研究进展作逐一综述,以便深入了解肿瘤微环境(tumor micro-environment,TME)、CAFs、EMT与肿瘤转移之间的相互关系,为肿瘤的治疗提供理论性指导。
With the development of social economy and the intensification of population aging,the incidence and mortality of tumors in the world are rising.Cancer metastasis is one of the important factors causing patients death.At present,many studies at home and abroad have shown that cancer associated fibroblasts(CAFs)can induce epithelial mesenchymal transition(EMT)through a variety of ways to improve the invasion and metastasis of tumor cells.Based on the research results on the relationship between CAFs and EMT at home and abroad,this paper aims to illustrate the recent research progress of CAFs promoting EMT in common tumors of digestive system,urogenital system and other systems,and summarize the recent research progress of the mechanism of CAFs inducing EMT in common tumors of each system one by one,so as to deeply understand the relationship between tumor micro-environment(TME),CAFs,EMT and tumor metastasis,which can provide theoretical guidance for the treatment of tumors.
作者
宗明慧
周杰
林铷
瞿旻晔
陈吉祥
ZONG Minghui;ZHOU Jie;LIN Ru;QU Minye;CHEN Jixiang(Department of General Surgery(Gastroenterology),Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China;Medical College,Jiangsu University,Zhenjiang 212000,China;Department of Sugery of Traditional Chinese Medicine,Affliated Hospital of Jiangsu University,Zhenjiang 212000,China)
出处
《现代医学》
2022年第8期1081-1087,共7页
Modern Medical Journal
基金
江苏省镇江市重点研发计划(社会发展)项目(SH2018082)
2020年度省中医药科技发展计划项目立项计划表——青年基金项目(QN202010)
2020年度江苏高校基础科学(自然科学)研究项目(20KJB360006)。
关键词
肿瘤微环境
肿瘤相关成纤维细胞
上皮-间质转化
tumor micro-environment
carcinoma-associated fibroblasts
epithelial-mesenchymal transition
