摘要
目的:研究NLRP3、TrkB与颅脑肿瘤术后伴抑郁的关系。方法:回顾性分析选取2018年10月—2020年10月长垣市中医医院收治的60例行颅脑肿瘤术患者作为研究对象。患者术后均接收汉密尔顿抑郁量表(hamilton depression Scale,HAMD)评分,将得分<8分的患者列入对照组(n=26),得分8~20分的患者列入抑郁组(n=34)。对比两组患者血清Nod样受体蛋白3(NOD-like receptor protein 3,NLRP3)和酪氨酸激酶B受体(tyrosine kinase receptor B,TrkB)水平;对血清NLRP3、TrkB与HAMD评分进行相关性分析,同时采用ROC曲线分析血清NLRP3、TrkB对颅脑肿瘤患者合并抑郁的预测价值。结果:实验组血清NLRP3显著高于对照组,且实验组的血清TrkB低于对照组,差异有统计学意义(t=0.086、0.312,P<0.05);实验组HAMD评分高于对照组,差异有统计学意义(t=52.294,P<0.05);血清NLRP3与HAMD评分呈正相关(r=0.622,P<0.001),血清TrkB与HAMD评分评分呈负相关(r=-0.587,P<0.001);血清NLRP3、TrkB对颅脑肿瘤患者合并抑郁的预测灵敏度和特异度均较高。结论:颅脑肿瘤术后伴抑郁患者血清NLRP3明显升高,血清TrkB明显降低,同时血清NLPR3和TrkB与患者抑郁程度具有明显相关性,并且对于颅脑肿瘤术后伴抑郁具有一定的预测价值。
Objective:To study the relationship between NLRP3,TrkB and depression after craniocerebral tumor surgery.Methods:A total of 60 patients with craniocerebral tumor who were admitted to the hospital from October 2018 to October 2020 were selected as the research subjects.All patients received the Hamilton Depression Scale(HAMD)score after operation.Patients with scores<8 points were included in the control group(n=26),and those with scores of 8-20 points were included in the depres⁃sion group(n=34).The serum levels of NOD-like receptor protein 3(NLRP3)and tyrosine kinase receptor B(TrkB)were compared between the two groups of patients.The correlation analysis between serum NLRP3,TrkB and HAMD score was carried out.The ROC curve was used to analyze the predictive value of serum NLRP3 and TrkB for depression in patients with craniocerebral tu⁃mor.Results:The serum NLRP3 in the experimental group was significantly higher than that in the control group,and the serum TrkB in the experimental group was lower than that in the control group,and the differences were statistically significant(t=0.086,0.312,P<0.05).The HAMD score of the experimental group was higher than that of the control group,and the difference was sta⁃tistically significant(t=52.294,P<0.05).Serum NLRP3 was positively correlated with HAMD score(r=0.622,P<0.001),serum TrkB was negatively correlated with HAMD score(r=-0.587,P<0.001).Serum NLRP3 and TrkB have high predictive sensitivi⁃ty and specificity for depression in patients with craniocerebral tumor.Conclusion:Serum NLRP3 was significantly increased and serum TrkB was significantly decreased in patients with depression after craniocerebral tumor surgery.At the same time,serum NLPR3 and TrkB were significantly correlated with the degree of depression in patients,and had a certain predictive value for de⁃pression after craniocerebral tumor surgery.
作者
赵运杰
ZHAO Yun-jie(Second Department of Surgery,Changyuan Hospital of Traditional Chinese Medicine,Xinxiang,Henan,453400,China)
出处
《黑龙江医学》
2022年第21期2595-2597,共3页
Heilongjiang Medical Journal
