摘要
目的探讨与分析异丙托溴铵联合特布他林对慢阻肺急性加重期患者的疗效。方法选择2020年1月~2022年1月在无锡市康复医院诊治的慢阻肺急性加重期患者88例作为研究对象,根据1∶1随机数表法原则把患者分为联合组与传统组,各44例。对照组给予异丙托溴铵治疗,联合组在对照组治疗的基础上给予特布他林治疗,两组都治疗观察3个月,观察两组患者的治疗效果。结果联合组治疗总有效率高于对照组,但差异无统计学意义(P>0.05)。联合组治疗期间的震颤、胃部不适、心悸等不良反应发生率与对照组相比,差异无统计学意义(P>0.05)。两组治疗后的第一秒呼出量(FEV1)占预计值百分比、FEV1/用力肺活量(FVC)都明显高于治疗前(P<0.05),联合组与对照组相比也明显升高(P<0.05)。两组治疗后的动脉二氧化碳分压(PaCO_(2))明显低于治疗前(P<0.05),血氧饱和度(SpO_(2))明显高于治疗前(P<0.05),治疗后联合组PaCO_(2)低于对照组,SpO_(2)高于对照组,差异有统计学意义(P<0.05)。两组治疗后的角色、躯体、情绪、认知和社会等生活质量评分均显著升高(P<0.05),且联合组治疗后的角色、躯体、认知和社会等生活质量评分都显著高于对照组(P<0.05)。结论异丙托溴铵联合特布他林在慢阻肺急性加重期患者的应用能提高患者的生活质量,能促进提高治疗效果,改善患者的肺功能,且不会增加不良反应的发生,还可促进恢复患者的血气状况。
Objective To explore and analysis the effi cacy of ipratropium bromide combined with terbutaline in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods From January 2020 to January 2022,88 cases of patients with acute exacerbation of chronic obstructive pulmonary disease who were diagnosed and treated in our hospital were selected as the research subjects.Accorded to therandom number table of 1:1,the patients were divided into the combined group and the control group with 44 cases in each group.The control group were given ipratropium bromide treatment,and the combined group were given terbutaline treatment on the basis of the treatment of the control group.Both groups were treated for 3 months,and the therapeutic eff ect of the patients were observed.Results The total eff ective rates of the combined group was higher than the control group,and the diff erence was not statistically signifi cant(P>0.05).The incidence rates of adverse reactions such as tremor,stomach discomfort,and palpitations during treatment in the combined group were not signifi cantly diff erent from those in the control group(P>0.05).After treatment,the percentage of exhaled volume in 1 second(FEV1)to the predicted value and FEV1/forced vital capacity(FVC)in the two groups were signifi cantly higher than those before treatment(P<0.05),and the combined group were also signifi cantly higher than the control group(P<0.05).The arterial partial pressure of carbon dioxide(PaCO_(2))in the two group after treatment were signifi cantly lower than that before treatment(P<0.05),and blood oxygen saturation(SpO_(2))was signifi cantly higher than that before treatment(P<0.05).And after treatment,the PaCO_(2) in the combined group was signifi cantly lower than the control group(P<0.05),the SpO_(2) was signifi cantly higher than the control group(P<0.05).The quality of life scores of role,body,emotion,cognition and society in the two groups after treatment were signifi cantly increased(P<0.05),and the scores of quality of life s
作者
左国璋
ZUO Guo-zhang(Department of Respiratory Medicine,Wuxi Rehabilitation Hospital,Wuxi Jiangsu,214001,China)
出处
《中华养生保健》
2022年第24期62-66,共5页
CHINESE HEALTH CARE
关键词
慢性阻塞性肺疾病
急性加重期
异丙托溴铵
特布他林
肺功能
血气状况
不良反应
生活质量
ipratropium bromide
terbutaline
acute exacerbation of chronic obstructive pulmonary disease
pulmonary function
blood gas status
adverse reactions
quality of life
