摘要
穴位是针刺刺激的初始应答部位,也是针刺起效的源头环节。针刺作为一种机械性物理刺激,其机械力在穴位如何转导为神经电信号和生物化学信号,穴位局部的理化信号如何启动针刺效应,是针刺作用原理研究中的共性、关键性源头问题。针刺手法引起穴位局部组织物理变化,如肌纤维的形变位移等,可作用于神经末梢感受器,产生神经电信号;也可激活穴区细胞膜上的机械敏感性离子通道,经细胞信号转导将物理信号转化为化学信号,触发穴位微环境理化耦合应答,通过神经和体液途径产生针刺效应。“针刺机械力”在穴位局部通过“理化换能”,促进机体感知并传递针刺信号,表明穴位是针刺物理化学信息耦合应答的“换能器”。
Acupoint is the initial response site of acupuncture stimulus and also the source link of the effect onset of acupuncture.Acupuncture is a mechanical physical stimulus.How is the mechanical force of acupuncture transduced into neuroelectrical and biochemical signals at acupoint?How does the physiochemical information of acupoint launch acupuncture effect?All of these remain the common and crucial questions in the study of acupuncture effect mechanism.Physical changes are induced in the local tissue of acupoint by needling techniques,such as the deformation and displacement of muscle fibers,which may act on the nerve ending receptors and produce electroneurographic signals.Besides,these changes may activate the mechanosensitive ion channels of the cytomembrane in acupoint site.Through cellular signal transduction,the physical signals may be transformed into chemical ones to trigger the physiochemical coupling response of acupoint microenvironment.Eventually,acupuncture effect is generated via nerves and body fluids."The mechanical force of acupuncture",through"the physiochemical transduction",promotes the body’s perception and transmits acupuncture signals.It suggests that acupoint is the"transducer"in the physiochemical information coupling response of acupuncture.
作者
窦报敏
徐枝芳
吕中茜
李柠岑
李艳伟
姚开芳
刘阳阳
王慎军
林小伟
郭义
DOU Bao-min;XU Zhi-fang;LV Zhong-xi;LI Ning-cen;LI Yan-wei;YAO Kai-fang;LIU Yang-yang;WANG Shen-jun;LIN Xiao-wei;GUO Yi(Research Center of Experimental Acupuncture Science,Tianjin University of TCM,Tianjin 301617,China;School of Chinese Medicine,Tianjin University of TCM,Tianjin 301617;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 301617)
出处
《中国针灸》
CAS
CSCD
北大核心
2022年第11期1321-1326,共6页
Chinese Acupuncture & Moxibustion
基金
国家自然科学基金重点项目:82030125。
关键词
穴位
针刺
机械敏感性离子通道
物理
化学
换能器
acupoint
acupuncture
mechanosensitive ion channels
physics
chemistry
transducer
