摘要
儿童急性肝衰竭(PALF)以伴或不伴有肝性脑病的严重肝功能障碍和凝血功能障碍为特征,病死率极高。肝移植的开展大大降低了PALF病死率,因此准确鉴别预后不良的病例对临床决策至关重要。本文就PALF预后影响因素(国际标准化比值、肝性脑病和血氨水平等)、预后评估模型(国王学院医院标准、小儿终末期肝病模型评分和肝脏损伤单元评分等),以及近年来研究较热门的生物标志物(血清维生素D结合蛋白和可溶性IL-2受体α等)进行综述。
Pediatric acute liver failure(PALF)is a kind of disease with high mortality rate,characterized by severe liver dysfunction and coagulation disorder with or without encephalopathy.liver transplantation improved the prognosis of PALF.The identification of poor outcome in PALF is necessary for clinical decision.The review concludes the recent prognostic factors of PALF,the prognostic model and the biomarkers.No optimal prognostic model has been developed for PALF so far,and further high-quality studies on larger cohorts are needed to determine the prognostic factors of PALF.
作者
毛俊文
孔元梅
张晓媛
方燕兰
Mao Junwen;Kong Yuanmei;Zhang Xiaoyuan;Fang Yanlan(Department of Pediatrics,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)
出处
《中华移植杂志（电子版）》
CAS
2022年第3期179-182,共4页
Chinese Journal of Transplantation(Electronic Edition)
关键词
急性肝衰竭
儿童
预后
评估
肝移植
Acute liver failure
Pediatrics
Prognosis
Assessment
Liver transplantation
