摘要
动脉粥样硬化斑块破裂是导致缺血性脑卒中急性发作的重要原因。微小核糖核酸(miRNA)是高度保守的、短的、单链的非编码RNA,因其在调控转录后基因表达方面起关键作用而被广泛关注。且诸多研究表明miRNA参与了动脉粥样硬化斑块破裂的各个环节,现就miRNA与动脉粥样硬化斑块破裂相关的纤维帽、坏死核心、巨噬细胞、新生血管等方面进行综述。
Rupture of atherosclerotic plaque is an important cause of acute ischemic stroke.MicroRNAs(miRNAs)are a class of highly conserved,short,single-stranded non-coding RNAs,which have attracted wide attention because of their key role in regulating post-transcriptional gene expression.Many studies have shown that miRNAs are involved in all aspects of atherosclerotic plaque rupture.This paper reviews the relationship of miRNAs with the fibrous cap,necrotic core,macrophages,and neovascularization related to atherosclerotic plaque rupture.
作者
冯佳佳
刘丹
张广炜
金丽霞
Feng Jiajia;Liu Dan;Zhang Guangwei;Jin Lixia(Department of Neurology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2022年第6期601-604,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
内蒙古自治区科技计划资助项目(201802129)。
