摘要
目的分析利伐沙班导致出血的主要影响因素以及出血后的处理,为临床安全用药提供参考,为药学监护提供思路。方法临床药师在心血管内科临床会诊病例中,收集2020年4月1日至2022年3月1日使用利伐沙班致出血病例10例,对患者的一般情况、用药、出血临床表现及停药后转归进行分析。结果使用利伐沙班致出血病例10例,均有时间关联性,停药、减量、针对原发病治疗后,出血得到改善,3例再激发阳性。结论利伐沙班致出血存在一些高危因素,且出血后处理措施因具体情况不同而有区别。临床药师应加强药学监护,关注患者相关疾病状态及合并用药情况,明确药学监护重点,确保用药安全;在患者出现ADR后,给出合理的建议,充分体现临床药师的价值。
OBJECTIVE Providing a reference point for the clinical safe use of medicines and ideas for pharmaceutical care by investigating main factors resulting in hemorrhage along with its post-treatment.METHODS Collecting 10 cases of bleeding caused by rivaroxaban from March 1,2020 to April 1,2022 during the clinical consultation in the Department of Cardiovascular Medicine,and analyzing the general situation,medication use,clinical manifestations of bleeding and appearance of drug withdrawal.RESULTS All of the 10 cases of bleeding caused by rivaroxaban were time-dependent.The bleeding was decreased after drug withdrawal,dosage reduction and treatment for the primary disease with 3 cases being re-positive.CONCLUSION There are high risk factors leading to the adverse reactions caused by rivaroxaban,and the post-treatment for hemorrhage varies largely contingent upon specific situations.In order to secure the safe use of medications,clinical pharmacists should strengthen the pharmaceutical care,pay attention to patients’ disease status and drug combination,and clarify the key points of pharmaceutical care.Specifically,appropriate advice should be provided when ADRsoccur,which could also fully reflect the high value of clinical pharmacists.
作者
尹松
周汨
陈熙
丁融
YIN Song;ZHOU Mi;CHEN Xi;DING Rong(Xiangtan Medicine&Health Vocational College,Xiangtan 421001,China;The First People′s Hospital of Xiangtan,Xiangtan 411101,China)
出处
《海峡药学》
2022年第10期80-83,共4页
Strait Pharmaceutical Journal
关键词
临床药师
利伐沙班
出血
药学实践
Clinical pharmacist
Rivaroxaban
Bleeding
Pharmacy practice
