摘要
目的:探究血清半乳糖凝集素-1(Gal-1)、谷胱甘肽过氧化物酶3(GPX3)对分化型甲状腺癌(DTC)术后^(131)I清甲治疗效果的评估价值。方法:106例DTC术后行^(131)I清甲治疗患者,根据术后6个月疗效将患者分为疗效满意(ER)组和疗效不满意(non-ER)组。收集两组一般资料及血清Gal-1、GPX3等生化指标水平,用单因素及Logistic回归模型分析各项指标与^(131)I清甲疗效的关系;用受试者工作特征曲线(ROC)分析血清Gal-1、GPX3对^(131)I清甲疗效的评估价值。结果:106例患者中,^(131)I治疗7 d后,清甲成功率为74.53%(79/106);术后6个月后,疗效ER者62例,入ER组,疗效non-ER者44例,入non-ER组。与non-ER组相比,ER组TSH、刺激性Tg、Gal-1水平均较低,Gal-1水平较高(P<0.05)。Logistic回归分析显示,TSH(OR=0.456)、刺激性Tg(OR=0.434)、Gal-1(OR=1.919)、GPX3(OR=0.494)均是^(131)I清甲疗效的独立影响因素(P<0.05)。ROC曲线分析显示,血清Gal-1、GPX3评估^(131)I清甲疗效的曲线下面积(AUC)分别为0.754、0.861;且以二者联合的诊断效能最大(AUC=0.956,敏感度=97.73%、特异度=83.87%)。结论:血清Gal-1、GPX3水平与^(131)I清甲疗效密切相关,二者联合用于DTC术后^(131)I清甲疗效评估具有一定参考价值。
Objective:To explore the evaluation value of serum galactose lectin-1(Gal-1)and glutathione peroxidase 3(GPX3)on the efficacy of ^(131)I treatment after differentiated thyroid carcinoma(DTC).Methods:A total of 106 patients with DTC who underwent ^(131)I treatment after operation,according to the curative effect after 6 months,the patients were divided into satisfactory curative effect(ER)group and unsatisfactory curative effect(non-ER)group.The general data and serum levels of Gal-1,GPX3 and other biochemical indicators were collected.The relationship between various indicators and the efficacy of ^(131)I treatment was analyzed by single factor and Logistic regression model.The evaluation value of serum Gal-1 and GPX3 on the efficacy of ^(131)I treatmente was analyzed by receiver operating characteristic curve(ROC).Results:Among 106 patients,the success rate of ^(131)I treatment was 74.53%(79/106)after 7 days of treatment.6 months later,62 patients achieved ER were enrolled in the ER group,44 patients achieved non-ER were enrolled in the non-ER group.Compared with non-ER group,TSH,stimulating Tg and Gal-1 levels in ER group were significantly lower,while Gal-1 level was significantly higher(P<0.05).Logistic regression analysis showed that TSH(OR=0.456),stimulating Tg(OR=0.434),Gal-1(OR=1.919)and GPX3(OR=0.494)were independent influencing factors of ^(131)I treatment effect(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum Gal-1 and GPX3 were 0.754 and 0.861,respectively.The combination of the two had the highest diagnostic efficiency[AUC=0.956,sensitivity=97.73%,specificity=83.87%].Conclusion:Serum Gal-1 and GPX3 levels are closely related to the efficacy of ^(131)I treatment,and the combination of the two has a certain reference value for the evaluation of the efficacy of ^(131)I treatment after DTC.
作者
刘映华
符国宏
郑杨慈
蔡西婷
LIU Ying-hua;FU Guo-hong;ZHENG Yang-ci;CAI Xi-ting(Department of Quality Control,Haikou Hospital of the Maternal and Child Health,Haikou 571100;Department of General Surgery,Sanya Central Hospital,Sanya 572000,Hainan,China)
出处
《川北医学院学报》
CAS
2022年第11期1451-1454,共4页
Journal of North Sichuan Medical College
基金
海南省卫生健康行业科研项目(20A200539)。
