摘要
多烯紫杉醇是天然抗肿瘤药物紫杉醇的衍生物,具有广谱、高效的抗肿瘤活性,但其溶解性低、组织分布广,限制了临床应用。刺激响应型纳米递送系统凭借其载体材料结构的多元性、环境敏感释药性,有效改善了多烯紫杉醇这些缺陷,在此基础上,修饰靶向因子可使药物靶向递送,改变药物的组织分布,进一步提高抗肿瘤效果。综述近年多烯紫杉醇刺激响应型及靶向因子修饰纳米递送系统的研究进展,提出其发展面临的挑战及未来趋势等关键问题,以期为多烯紫杉醇在抗肿瘤药物的研究开发方面提供参考。
Docetaxel,a derivative of natural antitumor drug paclitaxel,has broad-spectrum and highly effictive antitumor activity,but its low solubility and wide tissue distribution limit its clinical application.The stimulation responsive nano delivery system effectively improves the above defects by diversity of carrier material structure and environment sensitive drug release.On this basis,modifying the targeting factor can make the drug targeted delivery,change the organization distribution of the drug and further improve the antitumor effect.This paper reviews the research progress on stimulation responsive and modifier modified nano delivery system of docetaxel in recent years,and puts forward the key problems such as its development challenges and future trend,in order to provide reference for the research and development of docetaxel in antitumor drugs.
作者
隋芳茜
李杰雨
杨山景
姜海梅
杨诗宇
李凌军
蔡晓青
SUI Fang-qian;LI Jie-yu;YANG Shan-jing;JIANG Hai-mei;YANG Shi-yu;LI Ling-jun;CAI Xiao-qing(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第19期6296-6305,共10页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81803474)
山东中医药大学药学院“药苑育研”优秀研究生创新基金(2021-0027)。
关键词
多烯紫杉醇
刺激响应
靶向因子
抗肿瘤
纳米递送系统
docetaxel
stimulus response
targeting factor
antitumor activity
nano delivery system
