摘要
目的优化当归挥发油的包合工艺。方法以藁本内酯包合率、丁烯基苯酞包合率、包合物收率和综合评分为指标,以β-环糊精与挥发油配比、包合温度和包合时间为考察因素,采用Box-Behnken响应面法进行优化,确定了当归挥发油饱和水溶液法包合的最佳工艺条件。结果优化的包合工艺为β-环糊精与挥发油配比为8∶1、包合温度50℃、包合时间60 min。结论确定的包合工艺包合率、包合物收率较高,工艺稳定可行。
Objective To optimize f inclusion process of Angelica sinensis volatile oil.Methods Taking inclusion rate of ligustilide and 3-butenylphthalide,yield of inclusion compound and comprehensive score as index,β-CD-volatile oil ratio,inclusion temperature,and inclusion times factors as factors,Box-Behnken design-response surface method was used to optimize and confirm the technology of saturated aqueous solution process of Angelica sinensis volatile oil.Results The optimum technological conditions wereβ-CDvolatile oil ratio 8∶1,inclusion temperature 50℃,and inclusion time 60 min.Conclusion The optimal technological conditions have higher inclusion rate and yield,with stable and feasible process.
作者
沈庆国
唐云峰
屈玲霞
周娜
姜佳峰
孙艳
金凤
卢传广
关永霞
SHEN Qing-guo;TANG Yun-feng;QU Ling-xia;ZHOU Na;JIANG Jia-feng;SUN Yan;JIN Feng;LU Chuan-guang;GUAN Yong-xia(Lunan Hope Pharmaceutical Co.,Ltd.,Linyi 276006,China;State Key Laboratory of Generic Technology of Traditional Chinese Medicine of Lunan Pharmaceutical Group,Linyi 276006,China;Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China;Linyi University,Linyi 276005,China)
出处
《现代药物与临床》
CAS
2022年第10期2226-2231,共6页
Drugs & Clinic
基金
山东省重点研发计划(重大科技创新工程)项目(2020CXGC010505)
山东省新旧动能转换重大产业攻关项目(鲁动能办[2021]23号)
临沂市兰山区科技创新发展计划专项(2026)。
关键词
当归挥发油
藁本内酯
丁烯基苯酞
饱和水溶液法
包合率
包合物收率
综合评分
Box-Behnken响应面法
Angelica sinensis volatile oil
ligustilide
3-butenylphthalide
saturated aqueous solution process
inclusion rate
yield of inclusion
comprehensive score
Box-Behnken response surface methodology
