摘要
随着心肺复苏技术的发展,心脏骤停患者的救治成功率已有一定的提升.但是,心肺复苏后脑损伤的治疗效果仍不理想.本文通过先前研究与本课题组相关研究,总结心肺复苏后脑损伤的机制(经典机制介导的脑损伤、细胞外囊泡介导的脑损伤以及远端脏器介导的脑损伤)、神经功能评估(神经系统查体、血清生物标志物、脑电图、多模态评估等)和临床治疗(通气和氧疗策略、目标温度管理和药物治疗等)的最新研究进展,以期为心肺复苏后脑损伤的研究和治疗提供参考.
With the development of cardiopulmonary resuscitation technology, the success rate of treatment in patients with cardiac arrest has improved. However, the therapeutic effect on brain injury after cardiopulmonary resuscitation is unsatisfactory. To provide a reference for the research and treatment of postresuscitation brain injury, this study summarizes the latest research progress on the mechanisms of postresuscitation brain injury(such as classical mechanism-mediated brain injury, extracellular vesicle-mediated brain injury, and distal organ dysfunction-mediated brain injury), neurological function assessment(neurological examination, serum biomarkers,electroencephalography, multimodal evaluation, etc.), and clinical treatment(strategies of ventilation and oxygen therapy, targeted temperature management, drug therapy, etc.) by reviewing the literature and combining the relevant research findings of our research group.
作者
姚鹏
马雯
王智渊
唐颂龄
简孟瑶
周婷圆
向昕杰
周法庭
甘露
何亚荣
蒋耀文
曹钰
YAO Peng;MA Wen;WANG Zhiyuan;TANG Songling;JIAN Mengyao;ZHOU Tingyuan;XIANG Xinjie;ZHOU Fating;GAN Lu;HE Yarong;JIANG Yaowen;CAO Yu(Department of Emergency Medicine/Laboratory of Emergency Medicine,West China Hospital of Sichuan University,Chengdu 610041,China;Disaster Medical Center,Sichuan University,Chengdu 610041,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2022年第11期1715-1730,共16页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:82072135,82272241)
四川省科技计划项目(批准号:2021YFS0023,2020YJ0033)
四川大学华西医院学科卓越发展1·3·5工程项目(批准号:ZYJC18019)资助。
关键词
心肺复苏
脑损伤
机制
治疗
cardiopulmonary resuscitation
brain injury
mechanism
treatment
