摘要
目的探讨对气虚血瘀型糖尿病周围神经病变(diabetes peripheral neuropathy,DPN)患者予以黄芪桂枝五物汤治疗的效果。方法选取2021年1月—2022年1月邹城市中医院收治的84例糖尿病周围神经病变患者,所有患者经中医辨证分型为气虚血瘀型,随机分为两组,各42例,对照组予以常规西药治疗,观察组基于常规西药联合黄芪桂枝五物汤治疗。观察并对比两组临床疗效,检测两组治疗前后的血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)]、血脂指标[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)以及高密度脂蛋白胆固醇(HDL-C)]水平的变化,并比较两组治疗前后感觉神经传导速度(SNCV)和运动神经传导速度(MNCV)。结果观察组临床总有效率较对照组高,差异有统计学意义(P<0.05)。治疗前,两组血糖指标水平比较,差异无统计学意义(P>0.05);治疗后,观察组FPG、2 hPG以及HbA1c水平均较对照组低,差异有统计学意义(P<0.05)。治疗前,两组血脂指标水平比较,差异无统计学意义(P>0.05);治疗后,观察组TG、TC、LDL-C水平均较对照组低,HDL-C水平则较对照组高,差异有统计学意义(P<0.05)。治疗前,两组正中神经、腓总神经SNCV和MNCV比较,差异无统计学意义(P>0.05);治疗后,观察组正中神经、腓总神经SNCV和MNCV均较对照组高,差异有统计学意义(P<0.05)。结论对气虚血瘀型糖尿病周围神经病变患者予以黄芪桂枝五物汤治疗的效果显著,不仅可以促进糖代谢,进一步改善血脂状态,同时还能对机体感觉和神经传导加以调节,有效提高传导速度,继而强化周围神经功能,抑制周围神经病变,加快病情康复。
Objective To investigate the effect of Huangqi Guizhi Wuwu Decoction on patients with qi deficiency and blood stasis type diabetic peripheral neuropathy(DPN).Methods A total of 84 patients with diabetic peripheral neuropathy who were admitted to Zoucheng Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were selected.All patients were classified as Qi deficiency and blood stasis type by TCM syndrome differentiation,and were randomly divided into two groups,42 cases in each group.The control group was treated with conventional western medicine,while the observation group was treated with conventional western medicine combined with Huangqi Guizhi Wuwu Decoction.Observed and compared the clinical effects of the two groups,and detected the changes of blood glucose indicators[fasting blood glucose(FPG),postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c)],blood lipid indicators[triacylglycerol(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)]before and after treatment.Sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV)were observed before and after treatment in the two groups.Results The clinical total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in blood glucose index levels between the two groups(P>0.05).After treatment,the levels of FPG,2 hPG and HbA1c in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of blood lipid indexes between the two groups(P>0.05).After treatment,the levels of TG,TC,and LDL-C in the observation group were lower than those in the control group,while the levels of HDL-C were higher than those in the control group,and the difference was statistically significant(P<0.05).Before tr
作者
代芳
王增梅
刘飞
李颖超
丁燕
DAI Fang;WANG Zengmei;LIU Fei;LI Yingchao;DING Yan(Zoucheng Hospital of Traditional Chinese Medicine,Zoucheng,Shandong Province,273500 China)
出处
《糖尿病新世界》
2022年第19期9-13,共5页
Diabetes New World Magazine
基金
山东省中医药科技项目(青年项目)(2020Q100)。
关键词
气虚血瘀型
糖尿病
周围神经病变
黄芪桂枝五物汤
血脂
糖代谢
Qi deficiency and blood stasis type
diabetes mellitus
Peripheral neuropathy
Huangqi Guizhi Wuwu Decoction
Blood lipids
Glucose metabolism
