摘要
目的 探讨羟考酮注射液复合右美托咪定用于剖宫产术后镇痛的可行性及效果。方法 选取2020年4月—2021年4月徐州医科大学附属沭阳医院进行剖宫产手术的80例患者随机数字法分为对照组和观察组。对照组采用舒芬太尼进行治疗,观察组患者采用羟考酮、右美托咪定静脉输注。对比分析两组患者临床应用效果。结果 观察组患者术后镇痛效果优于对照组,术后6 h、12 h和24 h时视觉模拟评分(visual simulation score,VAS)和各时间点宫缩痛评分均明显低于对照组,舒适度评分(Bruggrmann comfort scale,BCS)明显高于对照组,差异有统计学意义(P <0.05)。术后48 h时切口VAS评分与对照组比较差异无统计学意义(P> 0.05)。观察组术后24 h和48 h血清催乳素(prolactin,PRL)高于对照组,初乳时间和术后排气时间比对照组更早,并发症发生率明显低于对照组,观察组产后72 h泌乳量明显高于对照组,差异有统计学意义(P <0.05)。结论 对于剖宫产术后镇痛采用注射液复合右美托咪定能够起到明显的效果,安全可靠性高,值得在临床上推广使用。
Objective To explore the feasibility and effect of oxycodone injection combined with dexmedetomidine for postoperative analgesia after cesarean section.Methods From April 2020 to 2021 April 2020,80 patients undergoing cesarean section in the Affiliated Shuyang Hospital of Xuzhou Medical University were randomly divided into control group and observation group.The patients in the control group were treated with sufentanil,while the patients in the observation group were treated with oxycodone and dexmedetomidine.The clinical effects of the two groups were compared and analyzed.Results The effect of postoperative analgesia in the observation group was better than that in the control group.The visual simulation score(VAS) and the score of uterine pain at 6 h,12 h and 24 h after operation in the observation group were significantly lower than those in the control group,the scores of Bruggrmann comfort scale(BCS) were significantly higher than that of the control group(P 0.05).The serum prolactin(PRL) of the observation group was higher than that of the control group at 24 h and 48 h after operation.The colostrum time and the exhaust time of the observation group were earlier than that of the control group.The complication rate of the observation group was lower than that of the control group,the amount of lactation 72 h after delivery in the observation group was significantly higher than that in the control group(P <0.05).Conclusion The injection combined with dexmedetomidine for postoperative analgesia after cesarean section has obvious effect,high safety and reliability,and is worth popularizing in clinical use.
作者
朱其飞
陶凤禹
ZHU Qifei;TAO Fengyu(Department of Anesthesiology,the Affiliated Shuyang Hospital of Xuzhou Medical University,Shuyang Jiangsu 223600,China)
出处
《中国卫生标准管理》
2022年第19期117-121,共5页
China Health Standard Management
关键词
羟考酮
右美托咪定
舒芬太尼
剖宫产
镇痛
血清泌乳素
oxycodone
dexmedetomidine
sufentanil
cesarean section
analgesia
serum prolactin
