摘要
目的探讨盐酸拉贝洛尔片联合硝酸甘油治疗妊娠期高血压对患者氧化应激反应和炎症因子的影响。方法选取2020年12月至2022年2月期间在安康市妇幼保健院妇产科确诊的80例妊娠期高血压患者进行研究,按照随机数表法分为对照组和研究组各40例。对照组患者采用盐酸拉贝洛尔片治疗,研究组患者采用硝酸甘油联合盐酸拉贝洛尔片治疗,7 d为一个疗程,均治疗两个疗程。治疗后,比较两组患者的治疗效果,以及治疗前后的血压指标[舒张压(DBP)、收缩压(SBP)、平均动脉压(MAP)]、氧化应激反应指标[过氧化脂(LPO)、丙二醛(MDA)、超氧化物歧化酶(SOD)]、炎症因子指标[血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C反应蛋白(CRP)]和血管内皮指标[血清内皮素(ET)、一氧化氮(NO)]水平;对两组患者孕期期间进行随访并比较胎儿不良妊娠结局发生情况。结果治疗后,研究组患者的治疗总有效率为97.5%,明显高于对照组的77.5%,差异有统计学意义(P<0.05);治疗前,两组患者的DBP、SBP、MAP、LPO、MDA、SOD、TNF-α、IL-6、CRP、ET、NO比较差异均无统计学意义(P>0.05);治疗后,两组患者的DBP、SBP、MAP均较治疗前降低,且研究组分别为(98.49±12.68)mmHg、(130.41±15.52)mmHg、(95.12±10.32)mmHg,明显低于对照组的(119.99±11.78)mmHg、(152.88±15.32)mmHg、(110.15±10.28)mmHg,差异均有统计学意义(P<0.05);治疗后,两组患者的SOD较治疗前升高,且研究组为(133.59±20.02)U/mL,明显高于对照组的(92.98±18.69)U/mL,差异均有统计学意义(P<0.05);治疗后,两组患者的LPO、MDA均较治疗前降低,且研究组分别为(6.33±1.76)mmol/L、(6.04±1.02)mmol/L,明显低于对照组的(9.97±1.89)mmol/L、(7.65±1.12)mmol/L,差异均有统计学意义(P<0.05);治疗后,两组患者的TNF-α、IL-6、CRP均较治疗前降低,且研究组分别为(10.68±1.07)μg/L、(21.56±3.02)ng/L、(8.08±1.09)mg/L,明显低于对照组的(18.22±1.17)μg/L�
Objective To investigate the effects of labetalol hydrochloride tablets combined with nitroglycerin on oxidative stress and inflammatory factors in patients with pregnancy-induced hypertension.Methods Eighty patients with pregnancy-induced hypertension diagnosed in Department of Obstetrics and Gynecology,Ankang Maternal and Child Health Hospital from December 2020 to February 2022 were selected for the study.According to the random number table method,they were divided into the control group and the study group,each with 40 patients.The patients in the control group were treated with labetalol hydrochloride tablets,and the patients in the study group were treated with nitroglycerin and labetalol hydrochloride tablets,with 7 days as a course of treatment,for 2 courses.After treatment,the treatment effects of the two groups were compared,as well as the blood pressure indicators[diastolic blood pressure(DBP),systolic blood pressure(SBP),mean arterial pressure(MAP)],oxidative stress response indicators[lipid peroxide(LPO),malondialdehyde(MDA),superoxide dismutase(SOD)],inflammatory factor indicators[serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)],and vascular endothelial index[serum endothelin(ET),nitric oxide(NO)]levels.The two groups of patients were followed up during pregnancy and the incidence of adverse pregnancy outcomes was compared between the two groups.Results After treatment,the total effective rate of the study group was 97.5%,which was significantly higher than 77.5%of the control group(P<0.05).Before treatment,there was no significant difference in DBP,SBP,MAP,LPO,MDA,SOD,TNF-α,IL-6,CRP,ET,and NO(P>0.05);after treatment,DBP,SBP,and MAP of the two groups were lower than those before treatment,and DBP,SBP,and MAP of the study group were(98.49±12.68)mmHg,(130.41±15.52)mmHg,and(95.12±10.32)mmHg,respective-ly,which were significantly lower than(119.99±11.78)mmHg,(152.88±15.32)mmHg,and(110.15±10.28)mmHg in the control group(P<0.05);after treatment,the SOD of the two
作者
陈典玲
尤克莎
代恒苹
CHEN Dian-ling;YOU Ke-sha;DAI Heng-ping(Department of Obstetrics and Gynecology,Ankang Maternal and Child Health Hospital,Ankang 725000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2022年第22期2881-2885,共5页
Hainan Medical Journal
基金
陕西省科技厅计划项目(编号:QS061-C33-22)。
关键词
妊娠期高血压
盐酸拉贝洛尔片
硝酸甘油
氧化应激反应
炎症因子
不良妊娠结局
Pregnancy-induced hypertension
Labetalol hydrochloride tablets
Nitroglycerin
Oxidative stress response
Inflammatory factors
Adverse pregnancy outcomes
