摘要
目的评价泮托拉唑联合其他治疗对急性胰腺炎患者的临床疗效和安全性。方法检索PubMed.EmBase.Cochrane Library.中国知网、万方数据库和维普数据库,纳入泮托拉唑联合其他治疗急性胰腺炎的有效性和安全性的随机对照试验,并用RevMan5.3软件进行Meta分析。结果最终纳入了22篇文献。Meta分析结果显示,在常规治疗基础上加用泮托拉唑治疗急性胰腺炎能提高治疗有效率〔OR=3.49,95%CI=2.43-5.01,P<O.00001〕、缩短腹痛时间〔MD=-1.94,95%CI=-2.38--1.50,P<0.00001〕、血淀粉酶恢复时间〔MD=-2.77,95%CI=-3.01--2.53,P<0.00001〕、尿淀粉酶恢复时间〔MD=-3.07,95%CI=-3.91--2.24,P<0.00001〕、平均住院时间〔MD=-1.80,95%CI=-3.48--0.12,P=0.04〕,并且安全性更高〔OR=0.37,95%CI=0.17〜0.83,P=0.02〕。结论在常规治疗基础上加用泮托拉唑治疗急性胰腺炎,疗效显著,安全性更好。
Objective To evaluate the clinical efficacy and safety of pantoprazole combined with other drugs in patients with acute pancreatitis.Methods Related randomized controlled trials were retrieved from PubMed,EmBase,the Cochrane Library,CNKI database,Wanfang database and Chinese VIP database.Trials that compared the efficacy and safety of pantoprazole combined with other drugs in the treatment of acute pancreatitis were included.Meta-analysis was performed using Review Manager Software 5.3.Results Twenty-two studies were included and assessed.The results of meta-analysis showed that the clinical effective rate〔OR=3.49,95%CI=2.43 to 5.01,P<0.00001〕and safety rate〔OR=0.37,95%CI=0.17 to 0.83,P=0.02〕were both significantly higher in the pantoprazole group than in the conventional treatment group.In addition,the relief time of abdominal pain[MD=-1.94,95%CI=-2,38 to-1.50,F<0.00001],the recovery time of blood amylase〔MD=-2.77,95%CI=-3.01 to-2.53,P<0.00001〕,that of urine amylase〔MD=-3.07,95%CI=-3.91 to-2.24,P<0.00001〕,and the average length of hospital stay〔MD=-1.80,95%CI=-3.48 to-0.12,P=0.04〕were all significantly shorter in the pantoprazole group than in the conventional treatment group.Conclusion The addition of pantoprazole to the conventional treatment of AP is more effective and safer than the conventional treatment used alone.
作者
刘彦会
韦孝晨
吴新安
LIU Yan-hui;WEI Xiao-chen;WU Xin-an(Hefei BOE Hospital,Hefei 230000,China)
出处
《解放军药学学报》
CAS
2022年第2期165-170,共6页
Pharmaceutical Journal of Chinese People's Liberation Army
