摘要
目的 探讨卡前列素氨丁三醇联合氨甲环酸治疗宫缩乏力性产后出血的临床效果。方法 选取60例宫缩乏力性产后出血产妇,根据随机数字表法分为对照组与研究组,每组30例。对照组给予卡前列素氨丁三醇治疗,研究组给予卡前列素氨丁三醇联合氨甲环酸治疗。对比两组产后出血情况、凝血功能指标以及不良反应发生情况。结果 研究组产后2、12、24h出血量均少于对照组,差异有统计学意义(P<0.05)。治疗前,两组活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)及D-二聚体(D-D)指标比较,差异无统计学意义(P>0.05);治疗后,研究组APTT、PT指标短于对照组,FIB指标高于对照组,D-D指标低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率3.33%与对照组的13.33%比较,差异无统计学意义(P>0.05)。结论 卡前列素氨丁三醇联合氨甲环酸治疗产妇宫缩乏力性产后出血疗效显著,可缩短止血时间,减少出血量,改善凝血功能,有利于子宫复旧,加快产后康复,且用药安全性较高,值得临床推广与应用。
Objective To investigate the clinical effect of carboprost tromethamine combined with tranexamic acid in the treatment of postpartum hemorrhage caused by uterine fatigue. Methods 60 cases of postpartum hemorrhage due to uterine fatigue were selected and divided into control group and study group according to the random number table method, with 30 cases in each group. The control group was treated with carboprost tromethamine, and the study group was treated with carboprost tromethamine combined with tranexamic acid. Postpartum hemorrhage, coagulation function indexes and adverse reactions were compared between the two groups. Results The amount of blood loss in the study group was less than that in the control group at 2, 12 and 24 hours after delivery, and the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in activated partial thromboplastin time(APTT), prothrombin time(PT), fibrinogen(FIB) and D-dimer(D-D) between the two groups(P>0.05). After treatment, the APTT and PT indexes of the study group were shorter than those of the control group, the FIB index was higher than that of the control group, and the D-D index was lower than that of the control group, and the differences were statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the study group(3.33%) and the control group(13.33%)(P>0.05). Conclusion Carboprost tromethamine combined with tranexamic acid is effective in the treatment of postpartum hemorrhage caused by uterine attrition, which can shorten the hemostasis time, reduce the amount of bleeding, improve the coagulation function, facilitate uterine recurrence, accelerate postpartum rehabilitation, and has high safety, which is worthy of clinical promotion and application.
作者
陈佳浴
Chen Jiayu(Department of Obstetrics,Suzhou Wuzhong People's Hospital,Suzhou 215100,China)
出处
《实用妇科内分泌电子杂志》
2021年第31期71-73,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
产后出血
卡前列素氨丁三醇
氨甲环酸
止血效果
凝血功能
Postpartum hemorrhage
Carboprost tromethamine
Tranexamic acid
Hemostatic effect
Coagulation function
