摘要
目的探究加味扶正抑瘤汤对宫颈癌化疗患者病灶血供及肿瘤标志物的影响。方法采用随机分组将本院2020年6月至2022年1月收治的87例宫颈癌患者分为研究组(n=44)与对照组(n=43)。对照组采用常规化疗手段治疗,研究组在此基础上联合使用加味扶正抑瘤汤。观察两组患者治疗前后的病灶血供、肿瘤血清标志物和生活质量评分。观察两组患者临床疗效与不良反应发生率。结果两组患者治疗前超声参数上升时间(RT)、平均渡越时间(mTT)、达峰时间(TTP)、峰值强度(IMAX)水平比较差异无统计学意义(P>0.05)。治疗后研究组mTT、TTP、IMAX、RT水平较对照组显著降低,比较差异具有统计学意义(P<0.05)。两组患者治疗前糖类抗原125(CA125)、癌胚抗原(CEA)、鳞状上皮细胞癌抗原(SCCA)水平比较差异无统计学意义(P>0.05)。治疗后研究组CA125、CEA、SCCA水平较对照组显著降低,比较差异具有统计学意义(P<0.05)。治疗前两组患者躯体、角色、情绪、社会评分比较差异无统计学意义(P>0.05)。治疗后研究组躯体、角色、情绪、社会评分较对照组显著升高,比较差异具有统计学意义(P<0.05)。治疗后研究组总有效率为56.82%显著高于对照组32.56%,比较差异具有统计学意义(P<0.05)。治疗后研究组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论加味扶正抑瘤汤能有效降低宫颈癌患者肿瘤标志物水平、改善病灶血供指标、提升患者生活质量,降低不良反应发生率。
Objective To investigate the effects of modified Fuzheng Yiliu decoction on blood supply and tumor markers in patients undergoing chemotherapy for cervical cancer.Methods The 87 cervical cancer patients admitted to our hospital from June 2020 to January 2022 were randomly divided into the study group(n=44)and the control group(w=43).The control group was treated with conventional chemotherapy.On this basis,the research group used Jiawei Fuzheng Yiliu Decoction in combination.The blood supply,tumor serum markers and quality of life scores of the two groups of patients before and after treatment were observed.The clinical efficacy and incidence of adverse reactions in the two groups were observed.Results There was no significant difference in the ultrasonic parameters rise time(RT),mean transit time(mTT),time to peak(TTP)and peak intensity(IMAX)between the two groups before treatment(P>0.05).After treatment,the levels of mTT,TTR IMAX and RT in the study group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the levels of carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)and squamous cell carcinoma antigen(SCCA)between the two groups before treatment(P>0.05).After treatment,the levels of CA125,CEA and SCCA in the study group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in physical,role,emotion and social scores between the two groups(P>0.05).After treatment,the physical,role,emotional and social scores of the study group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the total effective rate in the study group was 56.82%,which was significantly higher than that in the control group,which was 32.56%,and the difference was statistically significant(P<0.05).After treatment,the total incidence of adverse
作者
齐成秋
Qi Chengqiu(Department of Obstetrics and Gynecology,Mianyang Central Hospital,Mianyang,Sichuan 621000,China)
出处
《实用妇科内分泌电子杂志》
2022年第8期68-71,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
加味扶正抑瘤汤
宫颈癌
病灶血供
肿瘤标志物
Modified fuzheng yiliu decoction
Cervical cancer
Blood supply
Tumor markers
