摘要
目的:研究血清趋化因子、RNAKL及25-羟维生素D[25-hydroxy vitamin D,25(OH)D水平与类风湿关节炎疾病进展的相关性。方法:择取2019年1月至2021年12月于我院诊治的289例类风湿关节炎患者及同期于我院体检的100例健康体检者进行研究。利用28个关节疾病活动度评分将RA患者分为RA缓解组及RA活动组。监测RA患者和健康体检对象空腹血清趋化因子配体20(C-C chemokine ligand 20,CCL20)、RNAKL及25(OH)D水平,并以DAS28评分作为RA疾病进展的变量,分析以上指标与RA疾病进展的相关性。结果:与对照组健康对象比较,RA患者血清CCL20、RNAKL水平显著升高,25(OH)D水平显著降低,差异均有统计学意义(P<0.05);RA活动组患者血清CCL20、RNAKL水平显著高于RA缓解组患者,血清25(OH)D水平比较,RA活动组患者显著低于RA缓解组患者,差异均有统计学意义(P <0.05);以DAS28评分作为RA疾病进展的变量,血清CCL20、RNAKL水平与DAS28评分呈正相关(P <0.05),血清25(OH)D水平与DAS28评分呈负相关(P <0.05)。结论:血清CCL20、RNAKL、25(OH)D水平与RA疾病进展相关,可作为监测疾病活动性的生物学指标,协助医生综合、全面判断患者病情。
Objective:To analyze the correlation of serum chemokine,RNAKL and 25-hydroxy vitamin D[25(OH)D]levels with disease progression in rheumatoid arthritis.Methods:289 patients with rheumatoid arthritis diagnosed and treated in our hospital from January 2019 to December 2021,and 100 healthy subjects who underwent physical examination in our hospital simultaneously,were included for the study.RA patients were divided into RA remission group and RA activity group using disease activity score 28-jointcount.Fasting serum levels of C-C chemokine ligand 20(CCL20),RNAKL and 25(OH)D were determined in RA patients and healthy subjects.And DAS28 score was used as a variable of RA disease progression to analyze the correlation between the above indicators and RA disease progression.Results:Compared with the control group,the serum levels of CCL20 and RNAKL in RA patients were significantly increased,while the level of 25(OH)D was significantly decreased,the difference was statistically significant(P<0.05).Serum levels of CCL20 and RNAKL in RA activity group were significantly higher than those in RA remission group,the difference was statistically significant(P<0.05).Serum 25(OH)D levels in RA activity group were significantly lower than those in RA remission group,the difference was statistically significant(P<0.05).Using DAS28 score as a variable for RA disease progression,correlation analysis showed that serum CCL20 and RNAKL levels were positively correlated with the DAS28 score(P<0.05),while serum 25(OH)D levels were negatively correlated with the DAS28 score(P<0.05).Conclusion:Serum levels of CCL20,RNAKL and 25(OH)D are correlated with the progression of RA,and CCL20,RNAKL and 25(OH)D can be used as biological indicators to monitor disease activity and assist doctors to judge patients'conditions comprehensively.
作者
贾筠
杜望磊
肖广智
赵春红
杨西超
JIA Yun;DU Wanglei;XIAO Guangzhi(The First Affiliated Hospital of Air Force Military Medical University,ShaanxiXi'an 710032,China)
出处
《河北医学》
CAS
2022年第11期1826-1831,共6页
Hebei Medicine
基金
陕西省重点研发计划项目,(编号:2021SF-074)。
