摘要
目的:观察伽玛刀体部立体定向放疗(SBRT)联合肝动脉化疗栓塞术(TACE)治疗原发性肝癌患者的效果。方法:回顾性分析2019年1月至2020年12月郑州人民医院收治的106例原发性肝癌患者的临床资料,按治疗方案不同分为观察组(n=53)、对照组(n=53)。对照组采用TACE治疗,观察组采用伽玛刀SBRT联合TACE治疗。比较两组临床疗效、治疗前后肿瘤标志物指标[甲胎蛋白(AFP)、癌胚抗原(CEA)]水平、肝功能指标[天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)]水平,以及不良反应发生率和随访6个月生存率。结果:观察组治疗总有效率为62.26%(33/53),高于对照组的41.51%(22/53),差异有统计学意义(P<0.05);治疗后,两组血清AFP、CEA、AST、ALT、TBiL水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异均无统计学意义(P>0.05);随访6个月,观察组生存率为73.58%(39/53),高于对照组的49.06%(26/53),差异有统计学意义(P<0.05)。结论:伽玛刀SBRT联合TACE治疗原发性肝癌患者可提高治疗总有效率和生存率,降低肿瘤标志物指标和肝功能指标水平,效果优于单纯TACE治疗。
Objective:To observe effects of gamma knife stereotactic body radiotherapy(SBRT)combined with transcatheter arterial chemoembolization(TACE)in treatment of primary liver cancer.Methods:The clinical data of 106 primary liver cancer patients admitted to People’s Hospital of Zhengzhou from January 2019 to December 2020 were retrospectively analyzed.According to different treatment schemes,they were divided into observation group(n=53)and control group(n=53).The control group was treated with TACE,while the observation group was treated with gamma knife SBRT combined with TACE.The clinical efficacy,the levels of tumor marker indexes[alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA)],the liver function index[aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBiL)]levels,the incidence of adverse reactions,and the 6-month follow-up survival rate were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 62.26%(33/53),which was higher than 41.51%(22/53)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of serum AFP,CEA,AST,ALT and TBiL in the two groups were lower than those before the treatment,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).There were no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The 6-month follow-up showed that the survival rate of the observation group was 73.58%(39/53),which was higher than 49.06%(26/53)of the control group,and the difference was statistically significant(P<0.05).Conclusions:Gamma knife SBRT combined with TACE can improve the total effective rate and the survival rate of the primary liver cancer patients,and reduce the levels of tumor markers and liver function indexes.Moreover,it is superior to single TACE.
作者
张大勇
高华
ZHANG Dayong;GAO Hua(Gamma Knife Treatment Center of People’s Hospital of Zhengzhou,Zhengzhou 450053 Henan,China;Medical Imaging Department of Guancheng Hospital of Traditional Chinese Medicine,Zhengzhou 450047 Henan,China)
出处
《中国民康医学》
2022年第20期32-35,共4页
Medical Journal of Chinese People’s Health
关键词
原发性肝癌
伽玛刀
体部立体定向放疗
肝动脉化疗栓塞术
肿瘤标志物
肝功能
生存率
Primary liver cancer
Gamma knife
Stereotactic body radiotherapy
Transcatheter arterial chemoembolization
Tumor marker
Liver function
Survival rate
