摘要
目的了解广东肇庆怀集县农村妇女两年来“两癌”检测的阳性情况及高危型人乳头瘤病毒(HPV)的感染特点。方法对2018年1月—2019年12月24146名参与“两癌”免费检测的35~64岁、农村妇女的宫颈癌筛查结果进行分析。以高危型HPV检测作为初筛方法,结果为HPV16、18型阳性的转诊阴道镜检查,其它高危型HPV阳性则进行薄层宫颈液基细胞学检查(TCT),TCT结果严重于或等于未明确意义的非典型鳞状上皮(ASC-US)者转诊阴道镜,阴道镜结果可疑或异常者进行组织病理学检查。结果高危型HPV总检出率为9.35%,单独HPV16、18和其它高危型HPV的阳性检出率分别为0.70%、0.32%、7.72%,混合感染检出率为0.61%,高危型HPV总检出率最高的年龄段是60~64岁,检出率为11.22%。细胞学转诊率为65.63%,阴道镜转诊率为61.23%。宫颈癌前病变检出率为323.03/10万,宫颈癌的检出率为45.56/10万,早期诊断率为87.64%。宫颈癌前病变和宫颈癌的HPV16、18及混合感染占70.79%。结论该地区高危型HPV阳性率、宫颈癌前病变及宫颈癌检出率均较高,宫颈癌筛查异常者细胞学及阴道镜转诊率较低,提示该地区存在更高的宫颈癌发病风险。
Objective To understand the positive screening results and the infection characteristics of high-risk human papillomavirus(HPV)in Huaiji County,Guangdong Province,in the two years of the free standardization testing for rural women’s“two cancers”.Methods The cervical cancer screening results of 35~64 year-old women with rural household registration who volunteered to participate in the“two cancers”free testing for rural women in the region were analyzed.High-risk HPV testing was used as the primary screening method for cervical cancer.The results of HPV16 and 18 positive patients were directly referred to colposcopy.If other high-risk HPV was positive,thin-layer cervical fluid-based cytology(TCT)was perform on those patients,whose TCT result severer than atypical squamous cells of undetermined significance(ASC-US)were referred to colposcopy,and those with suspicious or abnormal colposcopy results were referred to histopathological examination.Results The total positive detection rate of high-risk HPV was 9.35%.The positive rates of HPV16,18 and other high-risk HPV were 0.70%,0.32%and 7.72%respectively,mixed infection rate was 0.61%.The age group with the highest overall positive rate of high-risk HPV is 60-64 years old,and the rate is 11.22%.The referral rate for cytology was 65.63%,and the referral rate for colposcopy was 61.23%.The positive rate of cervical precancerous lesions was 323.03/100000,the positive rate of cervical cancer was 45.5/100000,and the early diagnosis rate was 87.64%.HPV16,18 and HPV mixed infections of cervical precancerous lesions and cervical cancer accounted for 70.79%.Conclusions The positive rate of high-risk HPV,cervical precancerous lesions and cervical cancer positive rate were high in this area.The being referred rate of cytology and colposcopy in cervical cancer screening was low,suggesting that there was a higher incidence of cervical cancer in this area risk.
作者
黄千峰
何琴
何裕
邓娟琼
林杏芳
张秀
HUANG Qianfeng;HE Qin;HE Yu;DENG Juanqiong;LIN Xingfang;ZHANG Xiu(Department of Physical Examination,Guangdong Women and Children Hospital,Guangzhou 511400,China;Department of Social Service,Huaiji Women and Children Hospital,Zhaoqing 526400,China)
出处
《广州医药》
2022年第6期22-26,共5页
Guangzhou Medical Journal
基金
中国疾病预防控制中心妇幼保健中心科研项目(2019FYH003)。
