摘要
目的探讨叶酸联合阿司匹林对孕早期血同型半胱氨酸(Hcy)升高孕妇子痫前期(PE)的预防效果。方法102例孕早期血Hcy升高孕妇作为研究对象,分为对照组和试验组,每组各51例。对照组孕14周开始予以阿司匹林治疗,试验组孕14周予以叶酸+阿司匹林治疗。结果试验组PE发生率(15.69%)显著低于对照组(31.37%)(P<0.05);对照组和试验组治疗后(妊娠34周)血Hcy浓度较治疗前(妊娠14周)显著降低,且试验组降低幅度明显大于对照组(P<0.05)。对照组和试验组发生PE的孕妇治疗后血Hcy浓度明显高于非PE孕妇(P<0.05);PE孕妇与非PE孕妇中,试验组血Hcy浓度均低于对照组,但在发生PE的孕妇中,此差异更明显(P<0.05);对照组和试验组治疗后ATPP增加,24 h尿蛋白量显著降低,且试验组治疗后ATPP高于对照组,24 h尿蛋白量低于对照组,比较差异均有统计学意义(P<0.05);试验组早产、FGR、新生儿窒息、产后出血、胎盘早剥发生率均显著低于对照组(P<0.05)。结论叶酸联合阿司匹林对孕早期血Hcy升高孕妇可有效预防子痫前期,改善妊娠结局;叶酸联合阿司匹林能够降低孕妇血Hcy浓度,增加ATPP,降低24 h尿蛋白量,这可能在叶酸联合阿司匹林预防子痫前期中发挥了作用。
Objective To explore the preventive effect of folic acid combined with aspirin on preeclampsia(PE)in pregnant women with elevated serum homocysteine(Hcy).Methods 102 cases of pregnant women with elevated serum Hcy in the early pregnancy were selected as the research subjects.They were divided into the control group and the test group,51 cases in each group.The control group was treated with folic acid at 14 weeks of gestation,and the test group was treated with folic acid and aspirin at 14 weeks of gestation.Results The incidence of PE in the test group(15.69%)was significantly lower than that in the control group(31.37%)(P<0.05);the blood Hcy concentration of the control group and the test group after treatment(34 weeks of gestation)was significantly lower than that before treatment(14 weeks of gestation),and the reduction range of the test group was significantly greater than that of the control group(P<0.05);both in PE pregnant women and non PE pregnant women,the blood Hcy concentration in the test group was lower than that in the control group,but the difference was more obvious in pregnant women with PE(P<0.05);After treatment,the ATPP of the control group and the test group was significantly increased,and the 24 h urinary protein content was significantly decreased(P<0.05).The ATPP of the test group was higher than that of the control group,and the 24 h urinary protein content was lower than that of the control group.The difference was statistically significant(P<0.05);The incidence of premature birth,FGR,neonatal asphyxia,postpartum hemorrhage and placental abruption in the test group was significantly lower than that in the control group(P<0.05).Conclusion Folic acid combined with aspirin can effectively prevent preeclampsia and improve pregnancy outcomes in pregnant women with elevated serum Hcy in early pregnancy.Folic acid combined with aspirin can reduce maternal serum Hcy concentration,increase ATPP and decrease 24 h urinary protein,which may play a role in the prevention of preeclampsia by folic aci
作者
李阿莉
LI Ali(Department of gynaecology and obstetrics,Xifeng District People's Hospital,Qingyang City,Gansu Province,Qingyang 745000,China)
出处
《中国处方药》
2022年第11期124-126,共3页
Journal of China Prescription Drug
关键词
Hcy升高
孕早期
叶酸
阿司匹林
子痫前期
ATPP
24
h尿蛋白量
母婴结局
Hcy elevation
Early pregnancy
Folic acid
Aspirin
Preeclampsia
ATPP
24-hour urinary protein level
Maternal and infant outcomes
