摘要
目的:观察多奈哌齐联合胞磷胆碱钠对2型糖尿病(T2DM)合并阿尔茨海默病(AD)患者的治疗效果。方法:选取2018年10月-2021年10月南方医科大学附属东莞人民医院收治的60例T2DM合并AD患者为研究对象,采用随机数字表法,将60位患者分为治疗组和对照组,每组30例。治疗组给予多奈哌齐联合胞磷胆碱钠口服治疗,对照组给予多奈哌齐口服治疗。比较两组患者治疗前后蒙特利尔认知评估量表(MoCA)、简易精神状态量表(MMSE)、日常生活能力量表(ADL)、不良反应量表(TESS)评分情况。结果:治疗前,两组MoCA、ADL评分比较,差异无统计学意义(P>0.05);治疗后第16周,治疗组MoCA、ADL评分均高于对照组,差异有统计学意义(P<0.05)。治疗前,两组定向力、记忆力、注意力和计算力、回忆力、语言能力各项MMSE评分及总分比较,差异无统计学意义(P>0.05);治疗后第16周,治疗组定向力、记忆力、注意力和计算力、回忆力、语言能力各项MMSE评分及总分均高于对照组,差异有统计学意义(P<0.05)。治疗前后两组TESS评分比较,差异无统计学意义(P>0.05)。结论:多奈哌齐联合胞磷胆碱钠对T2DM合并AD患者的疗效确切,安全性良好,可提高患者日常生活能力,增强患者回忆力、语言能力等。
Objective:To observe the therapeutic effect of donepezil combined with citicoline sodium in treatment of patients with type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD).Methods:Sixty patients with T2DM and AD who were admitted to Dongguan People's Hospital affiliated to Southern Medical University from October 2018 to October 2021 were selected as the research objects,and 60 patients were divided into treatment group and control group by random number table method,with 30 patients in each group.The treatment group was treated with donepezil combined with citicoline sodium orally,and the control group was treated with donepezil orally.The scores of Montreal Cognitive Assessment(MoCA)scale,Mini-Mental State Examination(MMSE)scale,Activity of Daily Living(ADL)scale,Traumatic Exposure Severity Scale(TESS)for adverse reactions were compared between the two groups before and after treatment.Results:Before treatment,the MoCA and ADL scores showed no significant difference between the two groups(P>0.05).At 16 weeks after treatment,the MoCA and ADL scores in the treatment group were higher than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in MMSE scores of orientation,memory,attention and calculation,recall,language ability items and the total scores between the two groups(P>0.05).At 16 weeks after treatment,the MMSE scores of orientation,memory,attention and calculation,recall,language ability items and the total scores in the treatment group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in TESS scores between the two groups before and after treatment(P>0.05).Conclusion:Donepezil combined with citicoline sodium is effective and safe in the treatment of T2DM patients with AD,which can improve the ability of daily life,enhance the memory,language ability and other abilities of patients.
作者
赵家胜
苗海锋
刘玉华
郑燕冰
戴绍文
莫笑连
黎瀚明
吕科峰
Zhao Jia-sheng;Miao Hai-feng;Liu Yu-hua;Zheng Yan-bing;Dai Shao-wen;Mo Xiao-lian;Li Han-ming;Lv Ke-feng(Department of Geriatrics,Dongguan People's Hospital,Southern Medical University,Dongguan 523100,Guangdong;Province,China Department of Neurology,Dongguan People's Hospital,Southern Medical University,Dongguan 523100,Guangdong Province,China)
出处
《中国社区医师》
2022年第30期61-63,共3页
Chinese Community Doctors
基金
东莞市社会科技发展重点项目(编号201950715001178)。
关键词
多奈哌齐
胞磷胆碱钠
2型糖尿病
阿尔茨海默病
Donepezil
Citicoline sodium
Type 2 diabetes mellitus
Alzheimer's disease
