摘要
目的 探究奥拉帕利对铂敏感晚期卵巢癌患者进行维持治疗的效果。方法 选取150例铂敏感晚期卵巢癌患者,根据化疗后达到临床完全缓解(PR)或部分缓解(CR)是否口服奥拉帕利维持治疗,将患者分为试验组(化疗结束后8周内口服奥拉帕利片)与对照组(化疗后未特殊用药治疗),每组75例。比较两组肿瘤标志物、不良反应发生情况及生活质量。结果 治疗前,两组患者糖类抗原125(CA125)比较,差异无统计学意义(P>0.05);治疗后,两组患者CA125水平均明显比治疗前降低,且试验组显著低于对照组,差异有统计学意义(P<0.05)。试验组不良反应发生率为6.67%,与对照组的5.33%比较,差异无统计学意义(P>0.05)。治疗前,两组患者生活质量(QOL)评分比较,差异无统计学意义(P>0.05);治疗后,两组QOL评分与治疗前比较,差异无统计学意义(P>0.05);且试验组与对照组治疗后QOL评分比较,差异无统计学意义(P>0.05)。结论 铂敏感晚期卵巢癌患者采用奥拉帕利治疗的效果确切,且对患者生活影响小,不良反应少。
Objective To explore the effect of olaparil on maintenance therapy for platinum-sensitive advanced ovarian cancer patients.Methods 150 patients with platinum-sensitive advanced ovarian cancer were selected.According to whether they achieved clinical complete response(PR) or partial response(CR) after chemotherapy,the patients were divided into experimental group(oral olaparib within 8 weeks after the end of chemotherapy) and control group(no special drug treatment after chemotherapy),75 cases in each group.Tumor markers,incidence of adverse reactions and quality of life were compared between the two groups.Results Before treatment,there was no significant difference in carbohydrate antigen 125(CA125) between the two groups(P>0.05).After treatment,the levels of CA125 in the two groups were significantly lower than before treatment,and the experimental group was significantly lower than the conttol group,and the difference was statistically significant(P0.05).Before treatment,there was no significant difference in quality of life(QOL) score between the two groups(P>0.05).After treatment,there was no significant difference in QOL score between the two groups compared with before treatment(P>0.05).There was no significant difference in QOL score between the experimental group and the control group after treatment(P>0.05).Conclusion Olaparil has a definite effect on patients with platinum-sensitive advanced ovarian cancer,with little impact on patients’ life and fewer adverse reactions.
作者
谢祯芳
Xie Zhenfang(Department of Gynecology,Baoding First Central Hospital,Baoding 071000,China)
出处
《实用妇科内分泌电子杂志》
2021年第24期8-10,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
卵巢癌
铂敏感
奥拉帕利
肿瘤标志物
不良反应
生活质量
Ovarian cancer
Platinum sensitive
Olapali
Tumor markers
Adverse reactions
The quality of life
