摘要
目的:分析奥马珠单抗致不良反应(adverse drug reaction, ADR)的临床表现和特点,为临床安全用药提供参考。方法:检索中国知网、万方、维普、Web of Science、PubMed、Embase等数据库关于奥马珠单抗致ADR的个案报道并进行分析。结果:收集奥马珠单抗致ADR的个案报道26篇,共35例,其中男性9例(25.71%)、女性26例(74.29%),年龄分布以30~69岁居多(82.86%),发生时间大多在用药后1年内(87.27%),过敏反应主要集中在用药3个月内(66.67%),ADR以皮肤及其附件损害(48.78%)、呼吸系统损害(14.63%)和循环系统损害(12.19%)为主。多数患者对症处理后均好转,仅1例死亡,4例发生过敏反应的患者接受脱敏治疗并成功脱敏。结论:临床应用奥马珠单抗应加强ADR监测,防范严重ADR的发生,确保用药安全。
OBJECTIVE The characteristics and relative factors of adverse drug reactions(ADR) induced by omalizumab were analyzed, in order to provide reference for the clinical use of omalizumab properly.METHODS Case reports of ADR induced by omalizumab were analyzed by searching electronic databases(CNKI,Wanfang, VIP,Web of Science, PubMed and Embase).RESULTS A total of 26 publications were collected, with a total of 35 cases, including 9 males(25.71%)and 26 females(74.29%).The age distribution is mainly 30-69 years old(82.86%). Most of the ADR induced by omalizumab occurred within 1 year(87.27%),and the allergic reactions was more common in the first 3 months(66.67%)of the medication.ADRs mainly include skin and its appendage damage(48.78%),respiratory system damage(14.63%)and circulatory system damage(12.19%).Most patients with ADR improved after symptomatic treatment, only 1 died, and 4 patients with allergic reaction received desensitization treatment and successfully desensitized.CONCLUSIONS Clinicians and pharmacists should pay more attention to the ADRs of omalizumab, to prevent the occurrence of severe ADR and ensure drug safety.
作者
张红盼
孙燕燕
田丹丽
ZHANG Hong-pan;SUN Yan-yan;TIAN Dan-li(Department of Pharmacy,Tianjin Children's Hospital,Tianjin 300134,China;Department of Pharmacy,Tianjin First Central Hospital,Tianjin 300192,China)
出处
《中国医院药学杂志》
CAS
北大核心
2022年第18期1939-1942,共4页
Chinese Journal of Hospital Pharmacy
关键词
奥马珠单抗
不良反应
文献分析
过敏反应
omalizumab
adverse drug reaction
literature analysis
anaphylaxis
