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新生血管性青光眼患者实施抗VEGF药物联合PRP治疗的效果研究 被引量:6

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摘要 目的探讨新生血管性青光眼患者实施抗血管内皮生长因子(vascular endothelial growth factor,VEGF)药物联合视网膜激光光凝(panretinal photocoagulation,PRP)治疗的临床效果。方法选取2017年8月至2018年8月本院收治的84例新生血管性青光眼患者,按照其挂号就诊单上的病案号奇偶数分为观察组和对照组。其中,对照组仅行PRP治疗,观察组则采用抗VEGF药物联合PRP治疗。最终,对比分析两组患者的临床指标、临床疗效和不良反应发生率。结果两组研究对象的基线特征差异无统计学意义(P>0.05)。实施治疗后的结果显示:观察组的眼压、视网膜静脉循环时间、视野缺损值、视网膜神经纤维层厚度、VEGF水平和PDGF-C水平均低于对照组(P<0.05);观察组的总有效率(85.7%)高于对照组(61.3%)(P<0.05);观察组总体不良反应发生率(16.7%)低于对照组(38.1%),且对照组的前房出血发生率(19.1%)高于观察组(7.1%),差异均具有统计学意义。结论抗VEGF药物联合PRP治疗新生血管性青光眼的效果优于单纯PRP治疗,且可改善患者眼压、提高临床疗效,降低不良反应发生率。
作者 王琳 刘驰
出处 《中国卫生统计》 CSCD 北大核心 2022年第5期786-788,791,共4页 Chinese Journal of Health Statistics
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