摘要
目的探讨妊娠晚期合并新型冠状病毒Omicron变异株感染患者的临床表现、母婴垂直传播风险及感染预防与控制。方法回顾性分析3例于某三甲医院分娩的新型冠状病毒Omicron变异株感染产妇及其新生儿的临床特征、母婴结局及感染预防与控制措施。结果3例新型冠状病毒Omicron变异株感染产妇平均年龄29岁,平均孕周38^(+4)周。初始临床症状为咳嗽、咳痰1例,其余2例患者无新型冠状病毒肺炎的临床表现。所有患者行剖宫产终止妊娠,对产妇乳汁、阴道分泌物、脐血、羊水行新型冠状病毒核酸检测,结果均为阴性。新生儿出生后立即母婴分离,其中2例转入新生儿重症监护病房隔离病室单间治疗,住院期间每日进行新型冠状病毒核酸检测,结果均为阴性;另1例间隔24 h连续2次核酸结果阴性,转至隔离点隔离观察。产妇和新生儿均预后良好。结论本研究尚未发现新型冠状病毒Omicron变异株感染孕晚期产妇母婴垂直传播的证据。对于孕周足月或呼吸道症状加重产妇,建议及时终止妊娠,新生儿出生后立即母婴分离并严格隔离,以确保新生儿的安全。
Objective To explore the clinical manifestations,risk of maternal-infant vertical transmission,as well as prevention and control of infection in pregnant patients with SARS-CoV-2 Omicron variant infection in a tertiary first-class hospital during later stage of pregnancy.Methods Clinical features,puerperae and infant outcomes as well as infection prevention and control measures of 3 pregnant women with SARS-CoV-2 Omicron variant infection and their newborns delivered in a tertiary first-class hospital were retrospectively analyzed.Results The average age of 3 pregnant women with SARS-CoV-2 Omicron variant infection was 29 years old and the average gestational age was 38^(+4) weeks.The initial clinical symptoms of 1 case were cough and expectoration,and the other 2 patients had no clinical manifestations of coronavirus disease 2019.All patients terminated their pregnancy with cesarean section,and the maternal milk,vaginal secretion,umbilical cord blood and amniotic fluid were tested for SARS-CoV-2 nucleic acid,results were all negative.The mother and baby were separated immediately after the delivery of the newborn,2 newborns were transferred to isolation room of neonatal intensive care unit for treatment,SARS-CoV-2 nucleic acid test was performed daily during hospitalization,results were all negative;the third case had nega-tive nucleic acid results for two consecutive times at an interval of 24 hours,and was transferred to isolation loca-tion for observation.The prognosis of parturients and neonates were good.Conclusion Evidence of maternal-infant vertical transmission of SARS-CoV-2 Omicron variant infection during late pregnancy was not found in this study.For pregnant women with full-term pregnancy or with aggravated respiratory symptoms,it is recommended to terminate the pregnancy in time.After delivery,the mother and baby should be separated and strictly isolated to ensure the safety of the newborn.
作者
熊风
刘珉玉
庞水子
刘越
康秀华
程娜
向天新
XIONG Feng;LIU Min-yu;PANG Shui-zi;LIU Yue;KANG Xiu-hua;CHENG Na;XIANG Tian-xin(Department of Infection Control,First Affiliated Hospital of Nanchang University,Nanchang 360006,China;Department of Neurosurgery,First Affiliated Hospital of Nanchang University,Nanchang 360006,China;The Second Department of Infection,First Affiliated Hospital of Nanchang University,Nanchang 360006,China;Jiangxi Hospital of China-Japan Friendship Hospital,Nanchang 360006,China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2022年第11期1105-1109,共5页
Chinese Journal of Infection Control
基金
江西省卫生健康委员会科技计划项目(202210018)。
