摘要
目的探讨与分析司美格鲁肽联合胰岛素泵强化治疗对2型糖尿病(Type 2 diabetes mellitus,T2DM)患者内分泌代谢的影响。方法选择2021年9月~2022年3月在哈尔滨市第四医院就诊的2型糖尿病患者60例作为研究对象,根据随机数表法把患者分为司美格鲁肽组与对照组,各30例。对照组给予胰岛素泵强化治疗,司美格鲁肽组在对照组治疗的基础上给予司美格鲁肽治疗,两组都治疗观察3个月,测定与记录患者内分泌代谢变化情况。结果治疗后,两组的空腹血糖、餐后2 h血糖都显著低于治疗前,司美格鲁肽组也显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组总胆固醇、低密度脂蛋白胆固醇、甘油三酯水平都显著低于治疗前,高密度脂蛋白胆固醇都高于治疗前,差异有统计学意义(P<0.05),司美格鲁肽组总胆固醇、低密度脂蛋白胆固醇、甘油三酯水平低于对照组,高密度脂蛋白胆固醇高于对照组,差异有统计学意义(P<0.05)。治疗后,两组糖化血红蛋白都明显低于治疗前,C肽明显高于治疗前,差异有统计学意义(P<0.05),司美格鲁肽组糖化血红蛋白明显低于对照组,C肽明显高于对照组,差异有统计学意义(P<0.05)。治疗后,司美格鲁肽组活力、精神健康、生理职能、社会功能、情感职能、生理机能、总体健康、躯体疼痛等生存质量评分都显著高于对照组,差异有统计学意义(P<0.05)。结论司美格鲁肽联合胰岛素泵强化治疗在2型糖尿病患者中应用能促进降低空腹血糖、餐后2 h血糖、糖化血红蛋白水平,提高患者的C肽水平,还可改善患者的血脂水平,提高患者的生存质量。
Objective To investigate and analysis the effect of semaglutide combined with intensive insulin pump therapy on endocrine metabolism in patients with type 2 diabetes mellitus(T2DM).Methods A total of 60 patients with type 2 diabetes mellitus who were treated in the Endocrinology Department of the Fourth Hospital of Harbin were selected as the research subjects from September 2021 to March 2022,according to the random number table method,the patients were divided into the semaglutide group and the control group,with 30 cases in each group.The control group was given intensive insulin pump therapy,and the semaglutide group was given semaglutide treatment on the basis of the treatment of the control group.Both groups were treated for 3 months,and the endocrine and metabolic changes of the patients were measured and recorded.Results After treatment,the fasting blood glucose and 2 h postprandial blood glucose of the semaglutide group and the control group were signifi cantly lower than those before treatment(P<0.05),and the semaglutide group was also significantly lower than the control group(P<0.05).After treatment,the levels of total cholesterol,low-density lipoprotein cholesterol and triglyceride in the two groups were signifi cantly lower than those before treatment(P<0.05),and high-density lipoprotein cholesterol was higher than that before treatment(P<0.05),the levels of total cholesterol,low-density lipoprotein cholesterol and triglyceride in the semaglutide group were signifi cantly lower than those in the control group(P<0.05),and high-density lipoprotein cholesterol was higher than the control group(P<0.05).After treatment,the glycosylated hemoglobin in the two groups was signifi cantly lower than that before treatment(P<0.05),and the C-peptide was signifi cantly higher than that before treatment(P<0.05),the glycosylated hemoglobin in the semaglutide group was signifi cantly lower than that in the control group(P<0.05),and the C-peptide was significantly higher than that in the control group(P<0.05).The qual
作者
李媛红
马琳娜
LI Yuan-hong;MA Lin-na(Department of Endocrinology,the Fourth Hospital of Harbin,Harbin Heilongjiang,150026,China)
出处
《中华养生保健》
2022年第23期11-14,共4页
CHINESE HEALTH CARE
关键词
司美格鲁肽
胰岛素泵强化治疗
2型糖尿病
内分泌代谢
semaglutide
intensive insulin pump therapy
type 2 diabetes mellitus
endocrine metabolism
