摘要
目的 探讨术前血小板计数与淋巴细胞计数比值(PLR)、鳞状细胞癌抗原(SSC-Ag)水平与非小细胞肺癌(NSCLC)根治术后并辅助化疗患者预后的关系。方法 我院接受NSCLC根治术后并辅助化疗的NSCLC患者102例(研究组),根据预后分为预后良好组75例及预后不良组27例,选取同期健康体检者99例为对照组。比较研究组与对照组PLR、SCC-Ag水平;比较不同预后患者术前PLR、SCC-Ag水平;分析NSCLC患者的预后影响因素以及术前PLR、SCC-Ag对NSCLC根治术后并辅助化疗患者预后的预测价值。结果 研究组PLR、SCC-Ag水平高于对照组(P<0.05);102例患者均成功完成随访,预后良好组术前PLR、SCC-Ag水平低于预后不良组(P<0.05);鳞癌、PLR升高、SCC-Ag升高为NSCLC根治术后并辅助化疗患者预后的影响因素(P<0.05);联合PLR、SCC-Ag检测预测NSCLC根治术后并辅助化疗患者预后不良的灵敏度为77.20%,特异度为75.30%,AUC为0.885,高于PLR、SCC-Ag单独检测(P<0.05)。结论 相较于健康人群,NSCLC患者PLR、SCC-Ag水平均异常升高,同时术前PLR、SCC-Ag可用于预测评估NSCLC根治术后并辅助化疗患者预后。
Objective To investigate the relationship between the preoperative platelet count to lymphocyte count ratio(PLR) and level of squamous cell carcinoma antigen(SSC-Ag) and the prognosis of patients with adjuvant chemotherapy after radical resection of non-small cell lung cancer(NSCLC).Methods One hundred and two patients(study group) with NSCLC who underwent radical resection and adjuvant chemotherapy in our hospital were divided into a good prognosis group(n=75) and a poor prognosis group(n=27) according to their prognosis. Another 99 healthy subjects in the same period were selected as a control group. The levels of PLR and SCC-Ag were compared between the study group and the control group. The preoperative PLR and SCC-Ag levels of patients with different prognosis were compared. The prognostic influencing factors of NSCLC patients and the predictive value of preoperative PLR and SCC-Ag on the prognosis of patients with NSCLC after radical operation and adjuvant chemotherapy were analyzed.Results The levels of PLR and SCC-Ag in the study group were higher than those in the control group(P<0.05). All 102 patients successfully completed the follow-up. The preoperative PLR and SCC-Ag levels in the good prognosis group were lower than those in the poor prognosis group(P<0.05). Squamous cell carcinoma, PLR elevation and SCC-Ag elevation were the prognostic factors of patients with NSCLC after radical operation and adjuvant chemotherapy(P<0.05). The sensitivity, specificity and AUC of combined PLR and SCC-Ag were 77.20%, 75.30% and 0.885, respectively, which were higher than those of PLR and SCC-Ag alone(P<0.05).Conclusions Compared with the healthy population, the levels of PLR and SCC-Ag in patients with NSCLC are abnormally elevated. At the same time, preoperative PLR and SCC Ag can be used to predict and evaluate the prognosis of patients with NSCLC after radical operation and adjuvant chemotherapy.
作者
李阳
董红旭
李志杰
高硕
LI Yang;DONG Hong-xu;LI Zhi-jie;GAO Shuo(Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing 100038,China)
出处
《实用医院临床杂志》
2022年第6期158-161,共4页
Practical Journal of Clinical Medicine
