摘要
目的探讨来曲唑治疗子宫内膜异位症的临床疗效。方法选取10例子宫内膜异位症患者为研究对象,术后病理检查均证实为卵巢子宫内膜样囊肿。术后连服3个月来曲唑预防子宫内膜异位症复发,比较用药前后患者性激素、肝功能、肾功能及卵巢体积大小。结果患者用药后3个月雌二醇(E2)水平(42.30±20.39)pg/ml较用药前(96.48±10.03)pg/ml明显降低,差异有统计学意义(P<0.05)。用药前后患者卵泡刺激素(FSH)、促黄体生成素(LH)、睾酮(T)、泌乳素(PRL)、孕酮(P)水平比较,差异无统计学意义(P>0.05)。用药前后患者谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酐(Scr)、卵巢体积均在正常范围,比较差异无统计学意义(P>0.05)。术后至今随访3年无一例复发。结论子宫内膜异位症患者术后单用来曲唑预防复发评估有效,无明显不良反应。
Objective To investigate the clinical efficacy of letrozole in the treatment of endometriosis.Methods 10 patients with endometriosis were selected as the research objects.All patients were confirmed as ovarian endometrioid cyst by postoperative pathological examination.Trozole was taken for 3 months after operation to prevent recurrence of endometriosis.Sex hormone,liver function,renal function and ovarian volume were compared before and after treatment.Results The level of estradiol(E2)was(42.30±20.39)pg/ml after 3 months of treatment compared with(96.48±10.03)pg/ml before treatment,and the difference was statistically significant(P<0.05).There was no significant difference in the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),prolactin(PRL)and progesterone(P)before and after treatment(P>0.05).Alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine(Scr)and ovarian volume were in the normal range before and after treatment,and there was no significant difference(P>0.05).There was no recurrence after 3 years follow-up.Conclusion Letrozole alone is effective in preventing recurrence in patients with ovarian endometriosis after operation and has no obvious adverse reactions.
作者
董朝玉
杨丽菁
李寅
杨晓
林美岑
Dong Chaoyu;Yang Lijing;Li Yin;Yang Xiao;Lin Meicen(Department of Gynecology,The Third People's Hospital of Yunnan Province,Kunming 650011,China)
出处
《实用妇科内分泌电子杂志》
2022年第13期56-58,共3页
Electronic Journal of Practical Gynecological Endocrinology
基金
云南省应用基础研究计划项目(编号2018FD118)。
