摘要
目的通过对阿里极高海拔(海拔5000 m以上)地区藏族居民进行体检并分析结果,阐明该人群血液学指标特点及慢性高原病现况。方法采用方便样本,选择250名藏族居民进行血常规、血氧饱和度及心率测查。根据血红蛋白(Hb)水平及血氧饱和度(SpO)判断是否为慢性高原病。结果海拔5200 m地区藏族居民红细胞(RBC)、Hb、红细胞压积(HCT)均高于我国正常生理参考值,平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均红细胞血红蛋白浓度(MCHC)、白细胞(WBC)及血小板(PLT)位于参考值上限。男性藏族居民RBC、Hb、HCT、MCHC均高于女性,PLT低于女性,且差异有统计学意义。MCV、MCH、WBC在藏族居民不同性别间无统计学差异;该海拔地区居民SpO约为正常值的85%,相同年龄段不同性别藏族居民SpO男性高于女性,且差异有统计学意义,心率无统计学差异;该海拔地区慢性高原病患病率高达16.4%,且重体力劳动者患病率明显高于轻体力劳动者,差异具有统计学意义。结论高海拔缺氧环境引起当地居民血液RBC数量、Hb及SpO等指标变化,慢性高原病患病率明显增高。劳动强度是高海拔地区慢性高原病的患病风险因素之一。
Objective To clarify the hematological characteristics and current situation of chronic mountain sickness among Tibetan residents in extreme high altitude area(more than 5000 m above the sea level)of Ali district based on the analysis of physical examination and blood test results.Methods Totally 250 Tibetan residents were selected by convenient sampling for blood oxygen saturation(SpO),heart rate,and blood routine examination.Chronic mountain sickness was determined according to the hemoglobin(Hb)level and SpO.Results The red blood cell(RBC),Hb and hematocrit(HCT)of the Tibetan residents at 5200-meter altitude were all higher than the normal physiological reference range of China.Mean red blood cell volume(MCV),mean red blood cell hemoglobin content(MCH),mean red blood cell hemoglobin concentration(MCHC),white blood cell(WBC)and platelet(PLT)were in the upper limit of the reference value.The RBC,Hb,HCT and MCHC of male Tibetan residents were higher than those of females,while PLT was lower than that of females,with significant differences.There were no statistical differences in MCV,MCH or WBC among different genders of Tibetan residents.The SpOof the Tibetan residents was about 85%of the normal value,and the males had higher SpOthan the females in the same age group,and the difference was statistically significant,but the heart rate did not differ significantly.The prevalence rate of chronic mountain sickness in this area was as high as 16.4%,and the prevalence rate of heavy manual workers was significantly higher than that of light manual workers,with significant differences.Conclusion The high-altitude anoxic environment causes the changes in red blood cells,hemoglobin,and oxygen saturation of local residents,and the prevalence of chronic mountain sickness increases significantly.Labor intensity is one of the risk factors for chronic mountain sickness in high-altitude areas.
作者
邹远妩
袁志敏
刘小星
兰隆辉
次仁拉姆
宋春燕
史二丽
曾令霞
ZOU Yuanwu;YUAN Zhimin;LIU Xiaoxing;LAN Longhui;CIREN Lamu;SONG Chunyan;SHI Erli;ZENG Lingxia(Department of Clinical Laboratory,The People’s Hospital of Ali,Tibet Autonomous Region,Ali 859099;School of Public Health,Xi’an Jiaotong University,Xi’an 710061;Department of Clinical Laboratory,Tuberculosis Prevent&Care Hospital of Shaanxi Province,Xi’an 710100;Department of Clinical Laboratory,Shaanxi Provincial Tumor Hospital,Xi’an 710061;Department of Clinical Laboratory,Ali District Disease Control and Prevention Center of Tibet Autonomous Region,Ali 859099,China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2022年第6期895-900,共6页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
阿里地区科技计划项目(No.ALKJ-BJCZ-2021-12)。
关键词
极高海拔
藏族居民
慢性高原病
红细胞
血红蛋白
extremely high altitude
Tibetan resident
chronic mountain sickness
red blood cell
hemoglobin
