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磺达肝癸钠在预防髋关节置换术患者下肢深静脉血栓中的应用

Effect of fondaparinux on the prevention of deep vein thrombosis of the lower extremity in patients with hip arthroplasty
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摘要 目的:探讨使用磺达肝癸钠治疗髋关节置换术患者及预防下肢深静脉血栓(DVT)的效果。方法:选取82例患者随机分为实验组和对照组各41例,对照组予依诺肝素钠、实验组予磺达肝癸钠治疗,对比两组的疗效。结果:治疗后实验组患者的凝血酶时间、不良反应发生率明显低于对照组(P<0.05),但两组凝血酶原时间、活化部分凝血酶时间、纤维蛋白原水平、血浆黏度、全血高切黏度及全血低切黏度以及血流速度均无明显差异(P>0.05)。结论:关节置换术的患者使用磺达肝癸钠治疗更有助于预防DVT且安全有效,对凝血功能和血小板无明显影响,与依诺肝素钠相比具有一定的优势。 Objective:To investigate the effect of fondaparinux in the treatment of patients with hip arthroplasty and on the prevention of deep venous thrombosis(DVT)of lower extremity.Methods:A total of 82 patients with hip arthroplasty were selected and randomly divided into an experimental group and a control group with 41 cases each.The control group were treated with enoxaparin sodium while the experimental group with fondaparinux.The therapeutic effects were compared between the two groups.Results:The thrombin time and the incidence of adverse reactions were significantly shorter or lower in the experimental group than the control group(P<0.05),however,there were no statistically significant differences between the two groups in prothrombin time,activated partial thrombin time,fibrinogen level,plasma viscosity,whole blood high and low shear viscosity and blood flow velocity after treatment(P>0.05).Conclusion:The use of fondaparinux for patients with hip arthroplasty is more helpful in preventing DVT,safe and effective,and has no significant effect on blood coagulation function and platelets and certain advantages compared with enoxaparin sodium.
作者 黄强 付宇 陈思锋 HUANG Qiang;FU Yu;CHEN Sifeng(Department of Orthopedics,the People’s Hospital of Yichun City,Yichun 336000,China)
出处 《上海医药》 CAS 2022年第21期18-20,85,共4页 Shanghai Medical & Pharmaceutical Journal
关键词 磺达肝癸钠 髋关节置换术 下肢深静脉血栓 fondaparinux hip arthroplasty deep vein thrombosis of lower extremity
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