摘要
目的研究周围型肺癌MSCT影像表现及病理学特征与肿瘤浸润转移的相关性。方法选取本院2017年1月至2018年10月收治的63例周围型肺癌患者作为研究对象,回顾性整理分析所有患者临床、影像学资料,分析周围型肺癌MMP-2表达与其病理特征、MSCT征象及MSCT增强的关系。结果63例患者中MMP-2阳性表达者38例,阳性率为60.32%;周围型肺癌病理类型与MMP-2表达不相关(P﹥0.05),病理分级Ⅲ级MMP-2阳性表达占比76.92%,高于Ⅰ~Ⅱ级的48.65%(P﹤0.05)。MSCT征象中肿瘤的直径、深分叶征、棘突征、纵膈淋巴结转移与MMP-2表达密切相关(P﹤0.05),与毛刺征、胸膜凹陷征与MMP-2表达不相关(P﹥0.05)。MMP-2阳性表达者明显强化占比高于MMP-2阴性表达者(P﹤0.05)。结论MMP-2表达与周围型肺癌的病理分型、MSCT征象具有一定的相关性,通过分析影像学征象可评估周围型肺癌患者浸润转移相关信息。
Objective To investigate the correlation between MSCT imaging features and pathological features of peripheral lung cancer and tumor invasion and metastasis.Methods 63 patients with peripheral lung cancer treated in our hospital from January 2017 to October 2018 were selected as the objects,retrospective sorting and analysis of clinical and imaging data of all patients,and analysis of the relationship between the expression of MMP-2 and its pathological features,MSCT signs and MSCT enhancement in peripheral lung cancer.Results In the 63 patients,there were 38 patients with positive expression of MMP-2,the positive rate was 60.32%.The pathological types of peripheral lung cancer were not related to MMP-2 expression(P﹥0.05).The patients with MMP-2 positive expression in pathological gradeⅢaccounted for 76.92%,which was higher than 48.65%in gradeⅠ~Ⅱ(P﹤0.05).The tumor diameter,deep lobulation sign,spinous sign,and mediastinal lymph node metastasis were closely related to MMP-2 expression in MSCT signs(P﹤0.05),but burr sign and pleural depression were not related to MMP-2 expression(P﹥0.05).The proportion of significantly enhancement of patients with MMP-2 positive expression was significantly higher than that of patients with MMP-2 negative expression(P﹤0.05).Conclusion The expression of MMP-2 has some correlation with the pathological classification of peripheral lung cancer and MSCT signs.By analyzing the imaging signs,the information about the invasion and metastasis of patients with peripheral lung cancer can be evaluated.
作者
张继光
ZHANG Ji-guang(Department of Interventional Radiology,Handan Central Hospital,Handan 056000,Hebei Province,China)
出处
《中国CT和MRI杂志》
2022年第11期72-73,84,共3页
Chinese Journal of CT and MRI
基金
河北省卫健委课题(20171459)。
关键词
周围型肺癌
多层螺旋CT
病理学特征
肿瘤浸润转移
Peripheral Lung Cancer
Multi-Slice Spiral CT
Pathological Features
Invasion and Metastasis of Tumor
