摘要
目的探究动态对比增强MRI(DCE-MRI)在≤2cm肺良恶性结节中的诊断价值。方法以2018年3月至2021年2月≤2cm孤立性肺结节患者101例为研究对象,均给予DCE-MRI检查及穿刺活检。根据穿刺活检结果确定结节良恶性及具体类型,比较良性结节及恶性结节的DCE-MRI参数[容积转运常数(K^(trans))、血液回流常数(K_(ep))、细胞外间隙对比剂容积分数(V_(e))、血浆内对比剂容积分数(Vp)],分析其对良恶性结节的鉴别价值;比较肺腺癌及肺鳞癌的DCE-MRI参数,分析其对肺鳞癌及肺腺癌的鉴别价值,并比较不同类型良性结节的DCE-MRI参数。结果恶性结节的K^(trans)、K_(ep)、V_(e)、V_(p)值大于良性结节(P﹤0.05);K^(trans)、K_(ep)、V_(e)、V_(p)值鉴别良恶性肺结节的AUC分别为0.774、0.781、0.719、0.670;肺鳞癌的K^(trans)、K_(ep)值小于肺腺癌(P﹤0.05);K^(trans)、K_(ep)、V_(e)、V_(p)值鉴别良恶性肺结节的AUC分别为0.725、0.745、0.627、0.613;不同类型非良性结节的K^(trans)、K_(ep)、V_(e)、V_(p)值对比无明显差异(P﹥0.05)。结论K^(trans)、K_(ep)值对良恶性肺结节具有诊断价值,且对肺鳞癌及肺腺癌具有鉴别价值。
Objective To explore the diagnostic value of dynamic contrast-enhanced MRI(DCE-MRI)in benign and malignant lung nodules not longer than 2cm.Methods A total of 101 patients with solitary lung nodules not longer than 2cm were enrolled as the research objects between March 2018 and February 2021.All underwent DCE-MRI examination and needle biopsy.The benign and malignant nodules,and their specific types were determined based on biopsy results.DCE-MRI parameters[volume transfer constant(K^(trans)),blood reflux constant(K_(ep)),extracellular extravascular volume fraction(V_(e)),contrast agent volume fraction in plasma(Vp)]of benign and malignant nodules were compared.And their differential value for benign and malignant nodules was analyzed.DCE-MRI parameters between lung adenocarcinoma and lung squamous cell carcinoma were compared,and their differential value for lung squamous cell carcinoma and lung adenocarcinoma was analyzed.DCE-MRI parameters in different types of benign nodules were compared.Results K^(trans),K_(ep),V_(e)and V_(p)values of malignant nodules were greater than those of benign nodules(P﹤0.05).AUC values of K^(trans),K_(ep),V_(e)and V_(p)in the differential diagnosis of benign and malignant lung nodules were 0.774,0.781,0.719 and 0.670,respectively.K^(trans)and K_(ep) values of lung squamous cell carcinoma were lower than those of lung adenocarcinoma(P﹤0.05).AUC values of K^(trans),K_(ep),V_(e)and V_(p) in the differential diagnosis of lung adenocarcinoma and lung squamous cell carcinoma were 0.725,0.745,0.627 and 0.613,respectively.There was no significant difference in K^(trans),K_(ep),V_(e) and V_(p) values among different types of benign lung nodules(P﹥0.05).Conclusion K^(trans)and K_(ep) values are of diagnostic value for benign and malignant lung nodules,and are of differential value for lung squamous cell carcinoma and lung adenocarcinoma.
作者
余英芳
胡海霞
王小义
李昌德
马绍琴
YU Ying-fang;HU Hai-xia;WANG Xiao-yi;LI Chang-de;Ma Shao-qin(Department of Radiology,the Fourth People's Hospital of Qinghai Province,Xining 810001,Qinghai Province,China;Department of Imaging,Gansu Wuwei Academy of Medical Sciences,Wuwei 733000,Gansu Province,China)
出处
《中国CT和MRI杂志》
2022年第11期64-66,共3页
Chinese Journal of CT and MRI
关键词
动态对比增强MRI
直径≤2cm
肺良恶性结节
诊断价值
Dynamic Contrast-enhanced MRI
Diameter Not Longer Than 2cm
Benign and Malignant Lung Nodule
Diagnostic Value
