摘要
目的:探讨血清总胆红素(TBIL)、血小板分布宽度(PDW)、平均血小板体积(MPV)联合检测在妊娠期糖尿病(GDM患者早期肾损伤诊断中的应用价值。方法:回顾性分析2020年9月至2021年6月深圳市宝安区福永人民医院收治的136例GDM患者的临床资料,根据肾小球滤过率不同分为肾功能正常组(肾小球滤过率≥90 mL/min)68例与早期肾损伤组(60 mL/min≤肾小球滤过率<90 mL/min)68例,同时纳入同期68名健康体检孕妇作为对照组,比较三组肾功能相关指标[血尿素、胱抑素C(CysC)、血肌酐、β2-微球蛋白(β2-MG)、微量蛋白(mALB)]水平及MPV、TBIL、PDW水平,绘制受试者工作特征(ROC)曲线分析血清TBIL、PDW、MPV联合检测在GDM患者早期肾损伤诊断中的应用价值。结果:三组血尿素、血肌酐水平比较,差异均无统计学意义(P>0.05);早期肾损伤组和肾功能正常组Cys C、β2-MG、mALB水平均高于对照组,且早期肾损伤组高于肾功能正常组,差异有统计学意义(P<0.05);早期肾损伤组和肾功能正常组MPV、PDW水平均高于对照组,且早期肾损伤组高于肾功能正常组,早期肾损伤组和肾功能正常组TBIL水平均低于对照组,且早期肾损伤组低于肾功能正常组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,TBIL、PDW、MPV单项检测及联合检测的AUC分别为0.779、0.831、0.690、0.908,且联合检测高于单项检测,差异有统计学意义(P<0.05)。结论:TBIL、PDW、MPV水平联合检测在GDM患者早期肾损伤诊断中具有较高的应用价值。
Objective: To explore application value of combined detection of serum total bilirubin(TBIL), platelet distribution width(PDW and mean platelet volume(MPV) in diagnosis of early renal injury in patients with gestational diabetes mellitus(GDM). Methods: The clinical data of 136 patients with GDM admitted to Fuyong People’s Hospital of Bao’an District from September 2020 to June 2021 were retrospectively analyzed,and they were divided into normal renal function group(glomerular filtration rate ≥ 90 mL/min, 68 cases) and early kidney injury group(60 mL/min ≤ glomerular filtration rate <90 mL/min) according to different glomerular filtration rates, while 68 healthy pregnant women during the same period were included as control group. The levels of renal function indexes [blood urea, cystatin C(CysC), serum creatinine, β2-microglobulin(β2-MG),microprotein(mALB)], MPV, TBIL, and PDW were compared among the three groups. Receiver operating characteristic(ROC) curve was drawn to analyze the application value of combined detection of serum TBIL, PDW and MPV levels in the diagnosis of early renal injury in the patients with GDM. Results: There was no significant difference in the levels of blood urea and creatinine among the three groups(P>0.05). The levels of CysC,β2-MG and mALB in the early renal injury group were higher than those in the normal renal function group and the control group;those of the normal renal function group were higher than those of the control group;the differences were statistically significant(P<0.05). The levels of MPV and PDW in the early renal injury group were higher than those in the normal renal function group and the control group, and those of the normal renal function group were higher than those of the control group;the TBIL level in the early renal injury group was lower than those in the normal renal function group and the control group, and that of the normal renal function group were lower than that of the control group;and the differences were statistically significant(P<
作者
张微微
马剑霞
黄梦婵
ZHANG Weiwei;MA Jianxia;HUANG Mengchan(Department of Gynecology of Xintian Community Health Service Center of Fuyong People’s Hospital of Bao’an District,Shenzhen 518103 Guangdong,China;Department of Gynecology of Fuyong People’s Hospital of Bao’an District,Shenzhen 518103 Guangdong,China)
出处
《中国民康医学》
2022年第19期111-114,共4页
Medical Journal of Chinese People’s Health
基金
深圳市宝安区科技计划项目(2018JD198)。
