摘要
转移是影响肝癌复发和死亡的主要原因,而上皮-间质转化(EMT)是肝癌转移的重要机制。EMT受TGFβ、Wnt/β-catenin、Notch等多种信号通路介导的转录因子Snail、Twist、ZEB等的调控。抑制肝癌EMT相关分子和信号通路是抑制肝癌侵袭转移的重要途径。近年来研究表明,多种中药复方或其有效成分具有抑制肝癌侵袭转移的作用,阻滞或逆转肝癌细胞EMT是其重要的作用机制。本文对EMT的作用和调控机制,以及近年来中药及其来源的天然化合物通过调控细胞EMT抑制肝癌侵袭转移的研究进行概述,以期为肝癌转移的中医药防治提供科学依据,为肝癌治疗提供新思路。
Metastasis is an important factor for the high recurrence and mortality rates of hepatocellular carcinoma(HCC),and epithelial-mesenchymal transition(EMT)is an important mechanism of HCC metastasis.EMT is regulated by the transcription factors such as Snail,Twist,and ZEB which are mediated by a variety of signaling pathways including TGF-β,Wnt/β-catenin,and Notch.Inhibition of EMT-related molecules and signal pathways in HCC is considered as an important approach to inhibit the invasion and metastasis of HCC.Recent studies have shown that a variety of compound traditional Chinese medicine(TCM)formula or their effective constituents can inhibit the invasion and metastasis of HCC by arresting or reversing EMT in HCC.This article reviews the role and mechanism of EMT and recent studies on TCM drugs and their derived natural compounds in inhibiting the invasion and metastasis of HCC by regulating cell EMT,so as to provide a scientific basis for the TCM prevention and treatment of HCC metastasis and new ideas for HCC treatment.
作者
王珏
张春蕾
汤凯悦
郑培永
宋海燕
WANG Jue;ZHANG Chunlei;TANG Kaiyue;ZHENG Peiyong;SONG Haiyan(Institute of Digestive Diseases,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Emergency,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第11期2636-2642,共7页
Journal of Clinical Hepatology
基金
上海市自然科学基金资助项目(20ZR1458900)
上海市青年科技英才扬帆计划项目(20YF1450000)。
关键词
肝肿瘤
肿瘤转移
上皮-间质转化
中草药
Liver Neoplasms
Neoplasm Metastasis
Epithelial-Mesenchymal Transition
Drugs,Chinese Herbal
