摘要
目的:探讨系统免疫炎症指数(SII)预测老年食管癌根治性放疗患者预后效果。方法:回顾性研究2020年1月-2021年12月如东县人民医院肿瘤内科收治的接纳根治性放疗的老年人食管癌患者76例的临床资料,依据ROC曲线明确总存活率的SII、中性粒细胞/网织红细胞中性粒细胞比率(NLR)的最佳临界点。剖析SII水准与患者临床医学病理学主要参数的关联;制作Kaplan-Meier生存曲线,剖析系统性免疫炎症指标对患者预后的影响。选用COX回归分析开展单要素和多因素分析,剖析影响患者预后的危险因素。结果:76例患者随访5~24个月,其中53例死亡,23例存活;通过ROC曲线分析得到SII预测患者死亡的ROC曲线下的面积(AUC)为0.793,最佳临界值为737.48。NLR预测治疗前患者死亡的AUC为0.69,最佳临界值2.31;高SII组患者与低SII组患者比较,肿瘤分期Ⅲ期、低分化、最大直径>3.5 cm、NLR>2.32的所占比例更高,差异具有统计学意义(P<0.05)。结论:系统免疫炎症指标是危害老年人食管癌根治性放疗患者预后的危险因素。
Objective:To explore the effect of systemic immune inflammation index(SII)on predicting the prognosis outcome of elderly patients with radical radiotherapy for esophageal cancer.Methods:The clinical data of 76 elderly patients with esophageal cancer receiving radical radiotherapy in the Department of Oncology of Rudong County People's Hospital from January 2020 to December 2021 were retrospectively investigated.The optimal critical point of total survival rate SII and neutrophil/reticulocyte neutrophil ratio(NLR)were determined according to the ROC curve.The correlation between SII levels and the main parameters of clinical medical pathology of patients was analyzed;The Kaplan-Meier survival curve was plotted to analyze the effect of systemic immune inflammation index on patient's prognosis.COX regression analysis was selected to carry out univariate and multivariate analysis and analyze the risk factors affecting the prognosis of patients.Results:The 76 patients were followed up for 5 to 24 months,among them 53 cases died and 23 cases survived;ROC curve analysis showed that,the area under curve(AUC)of SII predicting death was 0.793,and the optimal cut-off value was 737.48.The AUC of NLR predicting pretreatment death was 0.69,and the optimal cut-off value was 2.31.The proportion of tumor stage III,low differentiation,maximum diameter>3.5 cm,NLR>2.32 in the high SII group was higher than that in the low SII group,and the difference was statistically significant(P<0.05).Conclusion:Systemic immune inflammation index is a risk factor for the prognosis of elderly patients with radical radiotherapy for esophageal cancer.
作者
王清清
朱小红
刘鹏
Wang Qing-qing;Zhu Xiao-hong;Liu Peng(Department of Oncology,Rudong County People's Hospital,Nantong 226400,Jiangsu Province,China)
出处
《中外医药研究》
2022年第5期132-134,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
食管肿瘤
系统免疫炎症指数
根治性放疗
预后
Esophageal tumor
Systemic immune inflammation index
Radical radiotherapy
Prognosis
