摘要
目的探讨阿司匹林联合氯吡格雷治疗冠心病心绞痛(coronary heart disease angina pectoris,CHDAP)远期疗效及对血脂的影响。方法选取CHDAP患者64例,分为对照组和观察组各32例。对照组给予阿司匹林肠溶片治疗,1次/d,100 mg/次,持续治疗4周。观察组在对照组基础上加用氯吡格雷治疗,1次/d,75 mg/次,持续治疗4周。比较两组心绞痛发作、血脂有无差异。结果治疗1个月,对照组随访期间再发心绞痛22例次,观察组再发心绞痛10例次,随访期间观察组心绞痛发生风险显著低于对照组,且差异有统计学意义(HR=0.32,95%CI:0.15~0.64,P<0.05);两组治疗前血脂水平差异无统计学意义(P>0.05),观察组治疗后优于对照组(P<0.05);两组治疗前血液流变学指标水平差异无统计学意义(P>0.05),观察组治疗后优于对照组(P<0.05)。结论阿司匹林联合氯吡格雷可降低患者血脂、改善血液流变学指标,降低心绞痛发生风险。
Objective To investigate the long-term efficacy of Aspirin combined with Clopidogrel in the treatment of coronary heart disease angina pectoris(CHDAP)and its influence on blood lipid.Methods 64 CHDAP patients were divided into control group and observation group(32 cases in each group).The control group was given Aspirin enteric-coated tablet,100 mg/time,once a day,for four weeks.Observation group was additionally treated with Clopidogrel,once a day,75 mg/time,for 4 weeks.The difference of angina pectoris attack and blood lipid was compared between the two groups.Results After 1 month of treatment,22 cases of recurrent angina pectoris occurred in the control group and 10 cases in the observation group during follow-up.The risk of recurrent angina pectoris in the observation group was lower(HR=0.32,95%CI:0.15-0.64,P<0.05).There was no significant difference in blood lipid levels between the two groups before treatment(P>0.05),and the observation group was better than the control group after treatment(P<0.05).There was no significant difference in hemorheological indexes levels between the two groups before treatment(P>0.05),and the observation group was better than the control group after treatment(P<0.05).Conclusion Aspirin combined with Clopidogrel can reduce blood lipid,improve hemorheological indexes and reduce the risk of angina pectoris.
作者
王伟
邱淑娟
WANG Wei;QIU Shu-juan(Department of Pharmacy,2.Department of Neurology,Jinghai District Hospital,Tianjin 301600,China)
出处
《中国血液流变学杂志》
CAS
2022年第2期242-245,共4页
Chinese Journal of Hemorheology
关键词
阿司匹林
氯吡格雷
冠心病
心绞痛
Aspirin
Clopidogrel
coronary heart disease
angina pectoris
