摘要
单核/巨噬细胞在心血管疾病(动脉粥样硬化、心肌缺血再灌注)的炎症过程中起重要作用。炎症发生时,单核细胞通过整合素与细胞黏附分子(CAMs)的相互作用募集至炎症组织,靶向炎症部位。直接使用巨噬细胞作为药物载体,用巨噬细胞膜蛋白工程设计仿生纳米颗粒,用巨噬细胞膜包裹纳米颗粒,以及用巨噬细胞外泌体作为药物载体,均可模拟单核/巨噬细胞的特性实现炎症靶向给药,对心血管疾病的诊断和治疗有重要价值。本文对基于巨噬细胞的药物递送系统在心血管疾病中的诊断与治疗进展作一综述。
Monocytes/macrophages play an important role in the inflammatory process of cardiovascular disease(atherosclerosis,myocardial ischemia-reperfusion).When inflammation occurs,monocytes are recruited into the inflammatory tissue through the interaction of integrins and cell adhesion molecules(CAMs),targeting the inflammatory sites.Using macrophages directly as drug carriers,engineering biomimetic nanoparticles with macrophage cell membrane proteins,encapsulating nanoparticles with macrophage membranes,or using macrophage exosomes as drug carriers to simulate mononuclear/macrophage characteristics for targeted drug delivery,are all of great value in the diagnosis and treatment of cardiovascular diseases.This paper reviews the progress macrophage-based drug delivery system in cardiovascular disease.
作者
孙帝力
陈婧
高金峰
谭海鹏
黄浙勇
王齐兵
SUN Di-li;CHEN Jing;GAO Jin-feng;TAN Hai-peng;HUANG Zhe-yong;WANG Qi-bing(Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai Institute of Cardiovascular Diseases,Shanghai 200032,China)
出处
《中国临床医学》
2022年第5期857-863,共7页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金(82070281)。
