摘要
目的利妥昔单抗(RTX)联合吉西他滨+地塞米松+顺铂(GDP)化疗对非霍奇金淋巴瘤(NHL)患者胸苷激酶-1(TK-1)水平、血小板功能恢复及总生存率的影响。方法选取2009年7月至2016年7月于解放军联勤保障部队第九八八医院郑州院区治疗的112例NHL患者为研究对象,根据治疗方法的不同分为GDP组和R-GDP组,GDP组60例,R-GDP组52例。GDP组仅接受GDP方案治疗,R-GDP组采用RTX联合GDP方案治疗。比较治疗前后两组患者免疫球蛋白(Ig)A、IgG、IgM及体液补体C3、C4、血清TK-1、血管内皮生长因子(VEGF)水平,以及治疗前后1、7及14 d白细胞(WBC)及血小板(PLT)变化情况和临床疗效、随访5年的总生存率及不良反应发生情况。结果两组患者治疗后免疫球蛋白水平及体液补体水平较治疗前降低,差异有统计学意义(P<0.05)。与GDP组比较,R-GDP组治疗后血清TK-1、VEGF水平较均降低,差异有统计学意义(P<0.05)。与GDP组治疗后14 d比较,R-GDP组治疗后14 d WBC、PLT水平升高,差异有统计学意义(P<0.05)。两组患者随访5年的总生存率比较,差异有统计学意义(P<0.05)。结论RTX联合GDP方案治疗NHL可有效降低患者的TK-1水平、促进血小板的恢复,提高总生存率。
Objective To investigate the effects of rituximab(RTX)combined with gemcitabine+dexamethasone+cisplatin(GDP)chemotherapy on thymidine kinase 1(TK-1)level,platelet function recovery and overall survival rate in patients with non-Hodgkin′s lymphoma(NHL).Methods 112 NHL patients treated in Zhengzhou Branch,988 Hospital of PLA Joint Logistic Support Force from July 2009 to July 2016 were selected as the study subjects.According to the different treatment methods,they were divided into GDP group and R-GDP group,with 60 cases in GDP group and 52 cases in R-GDP group.The GDP group only received the GDP regimen,while the R-GDP group received RTX combined with GDP regimen.The levels of immunoglobulin(Ig)A,IgG,IgM,complement C3,C4,serum TK-1 and vascular endothelial growth factor(VEGF)were compared between the two groups before and after treatment,the changes of white blood cell(WBC)and platelet(PLT)at 1,7 and 14 days before and after treatment were compared,and the clinical efficacy,overall survival rate at 5-year of follow-up and adverse reactions after treatment were compared.Results The levels of immunoglobulin and humoral complement in the two groups after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).Compared with the GDP group,the levels of serum TK-1 and VEGF in the R-GDP group after treatment were lower than those in the GDP group,the differences were statistically significant(P<0.05).The levels of WBC and PLT in R-GDP group 14 days after treatment were significantly higher than those in GDP group 14 days after treatment,the differences were statistically significant(P<0.05).There was a significant difference in the overall survival rate at 5-year of follow-up between the two groups(P<0.05).Conclusion RTX combined with GDP regimen in the treatment of NHL can effectively reduce TK-1 level,promote platelet recovery and improve overall survival rate.
作者
姬宏利
姬宏娟
丁平
JI Hongli;JI Hongjuan;DING Ping(Department of Oncology,Zhengzhou Branch,988 Hospital of PLA Joint Logistic Support Force,Zhengzhou,Henan 450042,China;Department of Special Diagnosis,Kaifeng Branch,988 Hospital of PLA Joint Logistic Support Force,Kaifeng,Henan 476000,China;Department of Cardiology,Zhengzhou Branch,988 Hospital of PLA Joint Logistic Support Force,Zhengzhou,Henan 450042,China)
出处
《检验医学与临床》
CAS
2022年第21期2962-2966,共5页
Laboratory Medicine and Clinic
