摘要
目的:分析皮肌炎(DM)患者肌电图(EMG)的表现和临床特征,为DM患者的临床诊治和预后提供参考依据。方法:回顾性分析2013年6月-2020年10月于昆明医科大学第二附属医院行EMG检查并被确诊为DM患者的住院病历资料。根据EMG结果分为EMG正常组和EMG异常组,对两组临床资料、EMG特点、实验室检查及并发症进行统计学分析。结果:共收集107例DM患者,EMG正常组18例,EMG异常组89例,其中肌源性损害者74例,近端肌肉受累者55例。EMG正常组住院天数比EMG异常组更长,发病年龄更大,且EMG正常组间质性肺疾病的发生率高于EMG异常组,差异均有统计学意义(P<0.05)。两组间其他发病情况、皮损特点、肌肉症状及肿瘤发生率的差异均无统计学意义(P>0.05)。EMG正常组红细胞、血红蛋白及血清IgA水平均高于EMG异常组(P<0.05);EMG异常组红细胞沉降率(ESR)高于EMG正常组(P<0.05)。两组患者激素使用情况及用量、免疫抑制剂的使用情况之间差异无统计学意义。结论:EMG异常组的DM患者多为四肢近端的肌源性损害,且合并间质性肺疾病的发生率更低。同时,EMG异常组的DM患者ESR更高,ESR可能作为评估患者病情的一个参考指标。
Objective:To analyze the electromyogram(EMG)manifestations and clinical characteristics of patients with dermatomyositis(DM)for clinical diagnosis,treatment,and prognosis.Methods:A retrospective study was performed on clinical data of patients diagnosed with DM and undergoing EMG in the Second Affliated Hospital of Kunming Medical University from June 2013 to October 2020.According to the results of EMG,the patients were divided into normal EMG group and abnormal EMG group.Statistical analysis of their clinical data,electromyographic characteristics,laboratory examinations and complications was conducted to compare the two groups.Results:Among the 107 DM patients enrolled,18 were in the normal EMG group and 89 in the abnormal EMG group.There were 74 cases of myogenic injury and 55 cases of proximal muscle involvement.The normal EMG group had longer hospital stay and older onset age compared to the abnormal EMG group(P<0.05).The incidence of interstitial lung disease in the normal EMG group was also higher than that in the abnormal EMG group(P<0.05).There was no statistically significant difference in the incidence of other diseases,skin lesion characteristics,muscle symptoms,and tumor incidence between the two groups(P>0.05).The average level of red blood clls,hemoglobin and serum IgA in the normal EMG group was higher than that in the abnormal EMG group(P<0.05);the ESR level in the normal EMG group was lower than that in the abnormal EMG group(P<0.05).There was no significant difference in the other laboratory indicators,hormone use and dosage,and immunosuppressant use between the two groups(P>0.05).Conclusions:DM patients with abnormal EMG are more likely to suffer myogenic damage in the proximal limbs,and they also have a lower incidence of interstitial lung disease.In addition,DM patients with abnormal EMG have a higher ESR level,indicating that ESR may be used as a reference index to evaluate the patient's condition.
作者
周娅丽
胥璟
杨静
曹文婷
袁李梅
杨继春
邓丹琪
ZHOU Ya-li;XU Jing;YANG Jing;CAO Wen-ting;YUAN Li-mei;YANG Ji-chun;DENG Dan-qi(Department of Dermatology and Venereology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China;Department of Epidemiology and Biostatistics,School of Population Medicine and Public Health,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2022年第11期644-647,共4页
Journal of Clinical Dermatology
基金
昆明医科大学研究生创新基金(项目编号:2020S191)资助项目。
关键词
皮肌炎
肌电图
回顾性分析
临床特征
dermatomyositis
electromyography
retrospective study
clinical characteristics
