摘要
NLRP6,a Nod-like receptor family member,has been shown to affect intestinal homeostasis and microbial colonization through organizing a huge protein complex called inflammasome.NLRP6 inflammasome promotes the cleavage and secretion of inflammatory cytokines or the cleavage of pore-forming Gasdermin D to initiate the inflammatory cell death called pyroptosis,which plays important roles in responding to pathogen invasion.However,questions about the ligand(s)that trigger NLRP6 inflammasome activation,or the mechanisms that how a ligand triggers NLRP6 inflammasome assembly,are emerging.In this mini-review,we summarize the current understandings of ligand recognition of NLRP6,the role of liquid-liquid phase separation in NLRP6 inflammasome assembly,and potential links with human health and diseases.
基金
supported by grants from the National Key R&D Program of China(Grant No.2018YFA0508000)(SZ)
the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB29030101)(SZ)
the National Natural Science Foundation of China(Grants No.82061148013,81822021,and 81821001)(SZ).
