摘要
癌症是目前人类共同面对的最主要健康威胁之一.因原癌基因和抑癌基因突变而产生的癌细胞是这类疾病的核心推手.但在癌症发生发展过程中,许多并未发生基因突变的机体正常细胞也会被募集进入肿瘤组织,与癌细胞发生复杂的相互作用并深刻影响疾病进展.肿瘤微环境对癌症发生发展,尤其是对肿瘤转移过程的重要影响正在得到越来越多的关注和认识.针对肿瘤微环境的癌症治疗方法,尤其是利用免疫系统组分的治疗方法提供了新的癌症治疗靶点和思路,正在革命性地改变癌症临床治疗模式.本文总结了关于肿瘤微环境影响癌症发生发展过程的一些最新研究进展,同时讨论了这一领域中尚未完全理解的一些关键问题以及深入了解肿瘤微环境可能带来的新的癌症治疗机会.
Cancer is a major health problem worldwide.The disease is driven by cancer cells that are generated through mutations in their oncogenes and tumor suppresser genes.However,during tumor initiation and development,many stromal cell types,which do not bear oncogenic mutations,play important roles via interacting with cancer cells.It has been increasingly recognized that the tumor microenvironment is essential for cancer development,particularly in the process of cancer metastasis.Importantly,novel methods that target tumor microenvironment,including the ones utilizing immune system to fight cancer,have substantially improved the clinical management of high-grade malignancies.Here we review the recent studies in this field,discuss some key questions that remain to be fully understood and identify new opportunities to treat cancer through targeting different components of the tumor microenvironment.
作者
张赟
王小凡
ZHANG Yun;WANG Xiao-Fan(State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Duke University Medical School,Durham 27708,USA)
出处
《中国科学：生命科学》
CSCD
北大核心
2022年第9期1377-1390,共14页
Scientia Sinica(Vitae)
关键词
癌症
肿瘤转移
肿瘤微环境
上皮间质转化
肿瘤干细胞
转移定殖生长
cancer
metastasis
tumor microenvironment
epithelial-mesenchymal transition(EMT)
cancer stem cell
metastatic colonization
