摘要
目的 观察耳穴贴压联合增强型体外反搏(EECP)及心可舒片治疗气滞血瘀型冠心病(CHD)伴焦虑抑郁的临床疗效及对患者心理状态和炎症因子的影响。方法 将112例气滞血瘀型CHD伴焦虑抑郁患者随机分为2组,对照组56例予EECP及心可舒片治疗,治疗组56例在对照组治疗基础上加用耳穴贴压治疗。2组均治疗8周。比较2组疗效;比较2组治疗前后胸痛(胸闷)评分变化;比较2组治疗前及治疗2、4、8周汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMA)评分变化;比较2组治疗前后炎症因子水平变化;比较2组治疗前后心率变异性(HRV)指标变化;观察2组不良反应发生情况。结果 治疗组总有效率94.64%(53/56),对照组总有效率80.36%(45/56),治疗组疗效优于对照组(P<0.05)。2组治疗后胸痛(胸闷)评分均较本组治疗前降低(P<0.05),治疗后治疗组胸痛(胸闷)评分低于对照组(P<0.05)。2组治疗2、4、8周HAMA评分、HAMD评分均较本组治疗前降低(P<0.05),2组治疗4、8周HAMA评分、HAMD评分均较本组治疗2周降低(P<0.05),2组治疗8周HAMA评分、HAMD评分均较本组治疗4周降低(P<0.05);治疗4、8周治疗组HAMA评分、HAMD评分均低于对照组治疗同期(P<0.05)。2组治疗后肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、C反应蛋白(CRP)水平均较本组治疗前降低(P<0.05),治疗后治疗组TNF-α、IL-6、CRP水平均低于对照组(P<0.05)。2组治疗后RR间期的平均值标准差(SDANN)、窦性心搏RR间期的标准差(SDNN)、SDNN指数(SDNNX)、相邻NN之差>50 ms的个数占总窦性心搏个数的百分比(pNN50)、连续RR间期差值的均方根(rMSSD)均较本组治疗前升高(P<0.05),治疗后治疗组SDANN、SDNN、SDNNX、pNN50、rMSSD均高于对照组(P<0.05)。治疗组不良反应发生率3.57%(2/56),对照组不良反应发生率14.29%(8/56),2组不良反应发生率比较差异有统计学意义(P<0.05)。结论 耳穴贴压联合EECP及心可舒片治疗气滞血�
Objective To explore the effects of auricular point sticking plus Xinkeshu plus enhanced external counterpulsation(EECP)on coronary heart disease(CHD)patients with anxiety and depression of blood stasis and corresponding effect of psychological state and inflammatory factors.Methods A total of 112 patients with CHD with anxiety&depression(blood stasis)were randomly assigned to the control group(n=56)and the treatment group(n=56).The control group received Xinkeshu+EECP,and the treatment group 56 patients additionally received auricular acupoint sticking on the basis of the control group.Both groups were treated for 8 weeks,the aiming was to compare the curative effect,chest pain/chest distress score,Hamilton anxiety rating scale(HAMA)and Hamilton depression rating scale(HAMD)on weeks 2,4,and 8 of the treatment,inflammatory factors,heart rate variability(HRV),adverse events(AE).Results The total effective rate was 94.64%(53/56)for the treatment group and 80.36%(45/56)for the control group,the better curative effect in the treatment group was more common(P<0.05).After treatment,chest pain/chest distress in both groups were lower than those before treatment(P<0.05),which in the treatment group was significantly lower than that in the control group(P<0.05).The scores of HAMA and HAMD in both groups on weeks 2,4,and 8 of treatment were lower than those before treatment(P<0.05),which in the treatment group were significantly lower than those in the current control group(P<0.05).HAMA and HAMD for 4-week and 8-week were lower than those for 2-week(P<0.05),HAMA and HAMD for 8-week was lower than those for 4-week(P<0.05).After treatment,the levels of tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and C-reactive protein(CRP)in the two groups were lower(P<0.05),which in the treatment group was prevalence(P<0.05).The standard deviation of the average R to R ECG intervals(SDANN),the standard deviation of RR intervals(SDNN),the SDNN index(SDNNX),percentage of adjacent NN intervals differing by more than 50 milliseconds(pNN5
作者
郭晓梅
刘艳军
翟瑶瑶
GUO Xiaomei;LIU Yanjun;ZHAI Yaoyao(Department of Cardiovascular,Qinhuangdao Traditional Chinese Medicine Hospital,Qinhuangdao,Hebei 066000)
出处
《河北中医》
2022年第9期1530-1534,共5页
Hebei Journal of Traditional Chinese Medicine
基金
秦皇岛市科学技术局科学技术研究与发展计划(编号:201902A112)。
关键词
冠心病
焦虑
抑郁
耳穴贴压
中药疗法
反搏动术
Coronary heart disease
Anxiety
Depression
Auricular point sticking
Chinese medicine therapy
counterpulsation
