摘要
目的探讨无创呼吸机对慢阻肺急性加重并发Ⅱ型呼吸衰竭患者各项指标(动脉血气指标、炎症因子)及CAT评分、BODE指数的影响。方法回顾性分析亳州市人民医院2021年1月—2021年12月的60例慢阻肺急性加重并发Ⅱ型呼吸衰竭住院患者的临床资料,比较治疗前后血气分析指标和血清中性粒细胞/淋巴细胞比值(NLR)、IL-6、CRP、D-D表达水平及CAT评分、BODE指数的变化。结果治疗前两组动脉血气指标(PaO_(2)、PaCO_(2)、SaO_(2))及外周血NLR、CRP、IL-6、D-D水平差异无统计学意义(P>0.05),治疗后观察组的PaO_(2)、SaO_(2)均明显高于对照组,PaCO_(2)明显低于对照组,治疗后观察组患者外周血NLR、CRP、IL-6、D-D水平均显著低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗前CAT1评分、BODE1指数比较差异无统计学意义(P>0.05),治疗后观察组CAT2评分、BODE2指数较对照组分数明显下降(P<0.05)。结论无创呼吸机应用可有效改善慢阻肺急性加重并发Ⅱ型呼吸衰竭患者的氧合状态,减轻机体的炎症反应,BODE指数分级下降,提高生活质量,从而改善患者病情及预后。
Objective To investigate the effect of non-invasive ventilator on various indicators(arterial blood gas indicators,inflammatory factors),CAT score,and BODE index in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated by typeⅡrespiratory failure.Methods The clinical data of 60 inpatients with AECOPD complicated with typeⅡrespiratory failure in Bozhou People′s Hospital from January 2021 to December 2021 were retrospectively analyzed,and the changes of blood gas analysis indexes,serum neutrophil/lymphocyte ratio(NLR),IL-6,CRP,D-D expression levels,CAT scores and BODE index before and after treatment were compared.Results Before treatment,there were no significant differences in arterial blood gas indexes(PO_(2),PCO_(2),SO_(2))and the levels of peripheral blood NLR,CRP,IL-6,and D-D between the two groups(P>0.05).After treatment,the PO_(2)and SO_(2)of the observation group were significantly higher than those in the control group,the PCO_(2)in the observation group was significantly lower than that in the control group,and the levels of peripheral blood NLR,CRP,IL-6,and D-D in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in CAT1 and BODE1 index scores between the two groups before treatment(P>0.05).After treatment,the CAT2 and BODE2 index scores in the observation group were significantly lower than those in the control group(P<0.05).Conclusion The application of non-invasive ventilator can effectively improve the oxygenation status of AECOPD patients with typeⅡrespiratory failure,reduce the body′s inflammatory response,reduce the BODE index classification,improve the quality of life,and thereby improve the patient′s condition and prognosis.
作者
赵妍
蒋亚林
瞿香坤
ZHAO Yan;JIANG Ya-lin;QU Xiang-kun(Department of Respiratory and Critical Care Medicine,Bozhou City People′s Hospital,Bozhou,Anhui 236800,China)
出处
《临床肺科杂志》
2022年第11期1687-1691,共5页
Journal of Clinical Pulmonary Medicine
基金
安徽省重点研究与开发计划项目(No.202104j07020052)
亳州市重点研发计划项目(No.bzzc2021019)。
关键词
慢性阻塞性肺疾病
呼吸衰竭
无创呼吸机
NRL
Chronic obstructive pulmonary disease
Respiratory failure
Non-invasive ventilator
NRL
