摘要
肝细胞癌(hepatocellular carcinoma,HCC)是最常见的恶性肿瘤之一,大多数患者确诊时已为晚期,失去手术治疗机会。HCC的生长、侵袭、转移及免疫耐受与肿瘤微环境(tumor microenvironment,TME)密切相关。TME是肿瘤细胞赖以生存的细胞环境,包括肿瘤间质、邻近细胞、血管、周边多种免疫细胞和免疫相关介质等组分。转化生长因子-β(transforming growth factor-β,TGF-β)是一组能调节细胞生长和分化的细胞因子,通过调节TME维持肝脏免疫耐受和免疫激活间的平衡。TGF-β参与HCC免疫抑制性微环境的建立,肿瘤细胞及其微环境可通过TGF-β调节免疫细胞的表型及功能,促进HCC免疫耐受实现免疫逃逸。阐明TGF-β在TME中的免疫调节作用有望为HCC免疫治疗提供新的靶向途径和生物标志物。
Hepatocellular carcinoma(HCC)is one of the most common types of malignant tumor,while most patients with HCC were not eligible for surgery when diagnosed at advanced stages.Growth,invasion,metastasis and immune tolerance of HCC are tightly correlated with tumor microenvironment(TME),which is the cellular environment for tumor cells to survive,including tumor stroma,adjacent cells,blood vessels,peripheral immune cells,immune-related mediators,etc.Transforming growth factor-β(TGF-β)is known to act as a multifunctional cytokine involved in cell growth and differentiation and plays a central role in keeping the balance between immune tolerance and immune activation by regulating TME.TGF-βis involved in the establishment of the immunosuppressive microenvironment of HCC.Tumor cells and TME can modulate the phenotype and function of immune cells through TGF-β,promote immune tolerance and achieve immune escape.To elucidate the immunomodulatory effect of TGF-βin TME will offer new potential targeting pathways and biomarkers for HCC immunotherapy.
作者
舒杨
何玲玲
高美欣
杨君茹
王世伟
张福阳
韦何瑞
肖凡
魏红山
Shu Yang;He Lingling;Gao Meixin;Yang Junru;Wang Shiwei;Zhang Fuyang;Wei Herui;Xiao Fan;Wei Hongshan(Department of Gastroenterology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Institiute of Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2022年第3期9-13,共5页
Chinese Journal of Liver Diseases：Electronic Version
基金
国家重点研发计划“中医药现代化研究”重点专项(2018YFC1705700)
北京市自然科学基金(7202071)
首都临床特色应用研究(Z181100001718084)
北京市医院管理中心消化内科学科协同发展中心专项(XXZ04)。
关键词
转化生长因子-Β
肝细胞癌
免疫调节作用
肿瘤微环境
Transforming growth factor-β
Hepatocellular carcinoma
Immuno-regulatory activity
Tumor microenvironment
